Browsing by Author "Busari, A. O."

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    Effect of Occupational exposure to Gasoline on Reproductive and Thyroid hormones among male Petrol station attendants in Kwara State
    (African Journal of Tropical Medicine and Biomedical Research, 2023-07) Adunmo Godwin O.; Seyi Taiwo; Ibrahim Muniru; Busari, A. O.
    Abstract Introduction: Petrol fume contain organic compounds that have been suggested to be endocrine disruptors. There is paucity of data on petrol fume-linked health challenges in Nigeria. Thus, we evaluated the effects of petrol fume exposure on blood levels of reproductive and thyroid hormones among petrol pump station attendants in Kwara state, Nigeria. Material and Methods: Eighty (80) petrol station attendants and fifty (50) non-occupationally exposed subjects were recruited as controls. Anthropometric indices were taken and fasting blood samples were collected after signing the consent form. Free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), testosterone, follicle stimulating hormone and luteinizing hormone were evaluated using standard techniques. Results: Average age and BMI of petrol fume-exposed subjects are 27.40±0.419 and 24.98±0.254 respectively and was not different from controls. Elevated FT3 and FT4 were evaluated with a decreased TSH level in the exposed group when compared with controls. In contrast, FSH, LH and testosterone were significantly reduced in exposed group when compared with control. Conclusion: The result of this study shows that petrol fume toxicants adversely alter thyroid and gonadal functions thereby modulating circulating levels of reproductive and thyroid hormones in male petrol station attendants in Kwara state. Keywords: Petrol fumes, thyroid hormones; reproductive hormones, infertility.
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    Nauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration
    (Published by Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria, 2021) Balogun, M. E.; Umahi, G. O.; Ayinde, T. O.; Oluwasola, A.; Busari, A. O.; Ajibola, K. A.; Yusuf, R. O.; Ojulari, L. S.
    Objective: The ethanolic leaf extract of N. latifolia (EENL) was investigated for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric acid secretion parameters and ulcerated areas were evaluated. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume, total acidity and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal injuries. Conclusion: The study suggests that EENL attenuates gastric acid secretion and ulceration induced by ethanol in Wistar rat. The observed pharmacological activities might be mediated via antisecretory and cytoprotective mechanisms.