Browsing by Author "Bamigboye, Mercy Obaleye"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies(Library and Publications Committee, University of Ilorin, Ilorin, Nigeria., 2019) Babamale, Halimah Funmilayo; Rajee, Abdullahi Ola; Obaleye, Joshua Ayoola; Lawal, Amudat; Bamigboye, Mercy Obaleye; Lawal, Misitura; Sa'ad, H.O.Some transition metal complexes of mixed artemether, ascorbic acid and lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GC-MS). The results revealed that the artemether and ascorbic acid are chelating ligands and coordinates through the oxygen of the carbonyl groups while lumefantrine coordinates through the hydroxyl group in a monodentate fashion. The metal complexes were investigated for biological activity using five bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas aeruginosa. It was observed that the synthesized complexes were more effective towards the five bacteria species than the free drugs.