Browsing by Author "Babamale, H. F."
Now showing 1 - 8 of 8
Results Per Page
Sort Options
Item Artemether- Lumefantrine Mixed Ligand Complexes: Synthesis and In vitro Antiplasmodial activity Studies(Published by Faculty of Natural Sciences, Al- Hikmah University, Ilorin, Nigeria, 2018-12-25) Rajee, A. O.; Babamale, H. F.; Lawal, M.; Ayinla, S. O.; Lawal, A.; Obaleye, J. A.Malaria is one of the main causes of mortality and morbidity in the world, endangering billions and affecting millions of people each year. Resistance to common antimalarial drugs has proven to be a challenging problem in malaria control. In an attempt to develop efficacious compounds against sensitive and multidrug resistant falciparum malaria, four new complexes of mixed ligands (artemether and lumefantrine) were synthesized using template method. Their antiplasmodial activity potential was evaluated and compared with chloroquine and the parent ligands. The compounds were active against the tested parasite strains. The presence of the metal ions significantly improved the antiplasmodial action against the drug-resistant parasite strains when compared to chloroquine. Additionally, their biological activity was assessed using several in vitro assays. Biological and physical properties were correlated to the antimalarial activity.Item Chelation, Characterization and Antimicrobial screening of Mixed Isoniazid - Vitamin C complexes(Faculty of Natural Sciences, Al- Hikmah University, Ilorin, Nigeria, 2017-05-04) Bamigboye, M. O.; Obaleye, J. A.; Lawal, A.; Babamale, H. F.; Ajibola, A. A.; Adimula, V. O.; Lawal, M.In this study, mixed Zn(II), Cu(II), Co(II) complexes of Isoniazid and vitamin C were synthesized and characterized by melting point, conductivity measurement, Fourier Transform Infra-red (FT-IR), Atomic Absorption Spectroscopy and elemental analyses. The bonding nature of the mixed parent ligands and the structure of the complexes were based on analytical and spectroscopic techniques. The complexes were proposed to have the formula [M1L1L2(Cl2)], [M2L1L2(SO4)], [M3L1L2(Cl2)] where M1 = Zn(II), M2 = Cu(II), M3= Co (II) L1= Isoniazid and L2 = Vitamin C. The infra-red data relate to the results of the most informative and indicative region. The result of spectra data confirmed that the two ligands were bidentate in their mode of coordination with the metal ions. The complexes are in octahedral geometry and the molar conductance was found to be non-electrolytic in nature. Antimicrobial test was carried out against four bacterial species namely Bacillus subtilus, Staphylococuss aureus, Escherichia coli and Pseudomonas aeroginosa. All the complexes showed higher antibacterial activity at the same concentration against the microorganisms used compared to the ligandsItem Enrichment of a Nigerian Calcite ore for Hydroxyapatite production(Australian Ceramic Society, 2016-10-20) Baba, A. A.; Womiloju, A. A.; Joda, A.; Lawal, A.; Babamale, H. F.; Alabi, A. G. F.; Adekola, F. A.In this study, Hydroxyapatite (HAp) powders have been prepared from Calcite ore of Nigerian origin using diammonium hydrogen phosphate as the Phosphorus source via hydrothermal method. The HAp powders formed is used to determine the chemical structure and nature of HAp crystals at different reaction temperature and time of operation were characterized by X-ray Fluorescence (XRF), X-ray Diffraction (XRD), Scanning Electron Microscope (SEM) coupled with Energy Dispersive X-ray (EDS) and Fourier Transform Infra-red (FT-IR) techniques. Using a set of experimental conditions, different morphology, crystallinity and stoichiometric ratios were obtained. At optimal conditions (1M (NH4)2HPO4, 850C, 6 hours reaction time), a rectangular, rod-like and layered HAp crystal formed yielded Ca/P molar ratio of 1.66 which is close to the stoichiometric HAp ratio of 1.67 required for biomedical applications.Item Issa, A(2019-11-22) Lawal, A.; Issa A.; Rajee, A. O.; Mamman, A.; Saadu, H. O.; Bamigboye, M. O.; Babamale, H. F.; Osuniran W.; Busari, H. K.Item Mixed Isonicotinylhydrazide – pyridoxine Metal omplexes: Synthesis, Characterization and Antimicrobial activity(The Library and Publications Committee, University of Ilorin, Ilorin, Nigeria., 2016-05-07) Lawal, M,; Obaleye, J. A.; Lawal, A.; Bamigboye, M. O.; Rajee, A. O.; Babamale, H. F.; Nnabuike, G. G.Some mixed metal complexes of isonicotinylhydrazide – pyridoxine have been synthesised and characterised by physical and spectroscopic studies such as melting point, conductivity measurement, TLC, FT-IR and UV-visible spectroscopy. The antimicrobial activities of the metal complexes were investigated against some clinical isolates of Eschericha Coli, Klebsiella Pneumonia, Pseudomonas aureginosa and Stapylococcus species using the agar well diffusion method. The result of the spectroscopic studies revealed that both isoniazid and pyridoxine behave as neutral bidentate ligands. The Isonicotinylhydrazide ligand coordinated through the carboxyl oxygen and amine nitrogen while pyridoxine coordinated through the oxygen of the hydroxyl group and nitrogen of the pyridine group. The result of antimicrobial activity shows that the metal complexes displayed higher inhibitory activity against the tested organisms than the parent ligandsItem Preparation, Characterization and Biological Studies of Metal Complexes of Mixed Ligands of Nicotinamide and Metronidazole(Nigerian Society of Biochemistry and Molecular Biology, 2017-10-25) Lawal, A.; Ayanwale, P. A.; Rajee, A. O,; Bamigboye, M. O,; Saadu, H. O.; Lawal, M.; Babamale, H. F.; Nnabuike, G. G.; Yunus Issa, M. T.; Amolegbe, S. A.The Mn2+, Fe2+, Cu2+, Co2+, Zn2+ and Ni2+ complexes of mixed nicotinamide and metronidazole were prepared and characterized using solubility, melting point, conductivity measurement, CHNO (carbon, hydrogen, nitrogen, oxygen) elemental analysis, powder X-ray diffraction and infrared spectroscopy . The results of the physical and spectroscopic data confirm the formation of the complexes. For nicotinamide, coordination of the metal to the ligands occurred through the nitrogen of the pyrimidine group, while for mertonidazole, coordination took place through the nitrogen of the amine group. The antibacterial activity of the complexes was carried out against Staphylococcus aureus, Pseudomonas aureginosa, Klebsiella spp, Escherichia coli and Candida spp. Only Cu(II) mixed complex had high inhibitory activity against all three bacteria species. The results of antifungal activity show that all the complexes have no inhibitory activity against the two fungi species compared with the corresponding ligandsItem Synthesis, Characterization and Antimicrobial activities of some Mixed Ascorbic acid –Nicotinamide Metal Complexes(Faculty of Science, Bayero University Kano. Nigeria, 2015-01-25) Lawal, A.; Amolegbe, S. A.; Rajee, A. O.; Babamale, H. F.; Yunus-Issa, M. T.The present study aimed at synthesizing copper(II) and zinc(II) complexes of mixed ascorbic acid and nicotinamide and physiochemically characterize by solubility test, melting point, conductivity t e s t , i n f r a r e d , e l e c t r o n i c a n d p r o t o n n u c l e a r m a g n e t i c r e s o n a n c e t e c h n i q u e s . T h e r e s u l t o f t h e physiochemical studies indicated 1:1 stoichiometry and were supported by the spectroscopic data. T h e a n t i m i c r o b i a l a c t i v i t i e s o f t h e m i x e d c o m p l e x e s w e r e c a r r i e d o u t a g a i n s t B a c i l l u s s u b t i l i s , Escherichia coli, Staphylococcus aureus, Penicillum , spp Aspergillus flavus and Aspergillus niger. The result of the infrared data showed that ascorbi c acid coordinates through the oxygen of the carbonyl group and that of enolic C-2 hydroxyl grou p, while nicotinamide coordinates through the nitrogen atom of the pyridine ring. The result of t he antimicrobial studies showed that the mixed complexes have higher inhibitory activity than the original ligands against the tested bacteria and fu ngi speciesItem Synthesis, Characterization and Biological Studies of Mixed Paracetamol - Ascorbic acid Metal Complexes(World Bank Assisted National Agriculture Research Projects (NAARP), Faculty of Science, University of Port-Harcourt, Nigeria, 2016-09-25) Babamale, H. F.; Lawal, A.; Oloyede, E. A.; Rajee, O. A.Mixed ligand-metal complexes of Paracetamol and Ascorbic acid were synthesized using FeCl2.4H2O, CuCl2.2H2O, NiCl2.6H2O, CoCl2.6H2O and ZnSO4 salts based on two concentrations (3mmol and 5mmol). The complexes were characterized using some physical techniques such as melting point, solubility, conductivity measurement and spectroscopic analyses such as UV-Visible spectroscopy, Atomic absorption spectroscopy, and Infrared spectroscopy. Based on the physical and spectroscopic results, the coordination of the metal was through the phenolic oxygen and carbonyl oxygen in paracetamol while it was through the carbonyl oxygen and C-2 hydroxyl group in ascorbic acid. The complexes were also screened for their antimicrobial activities against some isolates of Enterococcus faecalis, Staphylococcus aureus, Clostridium difficile, Klebsiella sp., Helicobacter pylori