Browsing by Author "Atunwa, Soliu A."

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    Haematological, Serum Biochemical and Histopathological Changes in Acute and Sub-Chronic Aqueous Extract of Oyster Mushroom in Male Wistar Rats
    (Faculty of Sciences, Rajshahi University, Bangladesh., 2023) Garuba, Taofeeq; Olabanji, Islamiyat T.; Awogboro, Mariam O.; Olahan, Ganiyu S.; Atunwa, Soliu A.; Ahmed, Akeem O.; Aremu, Abdulfatai; Bolaji Mashhod; Adegboye, A. A.; Sabiu, Saheed
    This study aimed at evaluating toxicological implications of aqueous P. ostreatus extract (POE) in male Wistar rats. POE was prepared in 1:10 (pulverized P. ostreatus : distilled water). In acute toxicity test, single oral dose of 2 mL/kg of POE was administered and observed for 28 days. The sub-chronic toxicity study was conducted by daily oral administration of graded doses (0.25, 0.50 and 0.75 mL/kg b.w) of the extract for 28 days. Clinical signs of toxicity, hematological, serum biochemical parameters and histopathological studies were subsequently evaluated. No treatment-related signs of toxicity or mortality in the animals were recorded in both toxicity tests. Rats administered with lowest dose of POE (25 mL/kg) had highest percentage weight gain. POE had no significant difference (P>0.05) on Red Blood Cell, White Blood Cell (WBC) and differential WBC, and serum biochemistry across all the treated groups when compared to the controls. The result of photomicrographs of stomach, spleen, heart, lung, kidney and liver showed a well outlined arrays of normal tissues in both acute and sub-chronic doses connoting that POE had no toxic effect on them. In view of these, POE may be concluded to be non-toxic within the tested doses and period of investigation
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    Knowledge and Practice of Reporting of Adverse Drug Reactions among Community Pharmacists in Ilorin, North-Central, Nigeria
    (Journal of Pharmaceutical Research, Development and Practice, 2018-12) Bello, Nusirat O.; Atunwa, Soliu A.
    Background: Pharmacovigilance (PV) is the universal collation of adverse drug reactions (ADRs) intended to enhance the understanding of safety of medicines globally. Reporting of ADRs by healthcare professionals is vital for the success of PV. Objectives: To examine knowledge and practice of reporting of ADRs among community pharmacists (CPs) in Ilorin. Materials and Methods: A cross sectional survey was carried out using self-administered questionnaire developed for the purpose of the study among CPs present at their monthly meeting in March, 2016. Results: Majority of the CPs were male (15 CPs; 78.95%), mean age of 46.06 years and duration of practice ranged from 2 to 30 years. Almost half of the CPs (47%) had no additional formal training and virtually all the CPs (84%) would like training on ADRs reporting. More than half of the CPs (58%) never reported ADRs identified from patients and one-fifth would only report when certain that the reaction was caused by the drug. CPs expressed concerns in reporting such as non-availability of ADR reporting yellow forms. Conclusion: The study revealed moderate reporting of ADRs among CPs and suggests the need for appropriate and timely trainings of CPs on the reporting of ADRs and access to resources for proper reporting of ADRs. Larger studies are recommended to corroborate and further explore the findings of the study. ___________________________________________________________________________ Key words: Adverse Drug Reactions; Pharmacovigilance; Spontaneous Reporting; Community Pharmacists; National Pharmacovigilance Centre; NAFDAC