Browsing by Author "Akinlolu A.A."

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    Cephalometric study of mouth morphology among major Nigerian tribes
    (Association of Anatomical Societies of Africa, 2015) Akinlolu A.A.; Akinola B.O.; Nurudeen R.L.; Kadir R.E.; Ajao M.S.
    We tested the hypothesis that Nigerians of the three major tribes of Yoruba, Hausa and Igbo are of similar cephalometric parameters (morphological patterns) of the lips and mouth. 300 subjects were selected from each of Hausa, Igbo or Yoruba tribe. A total of nine hundred (900) randomly selected volunteered subjects aged 18 – 30 years (450 males and 450 females) who were of Hausa, Igbo or Yoruba tribe by both parent and grandparents were, therefore, used in the study. Cephalometric parameters measured include: width of the philtrum, width of the mouth (length of the labial fissure), height of the upper lip, height of the cutaneous upper lip, height of the cutaneous lower lip, height of the lower lip, depth of the body of mandible and the vermilion heights of upper and lower lips. The statistical significance of the differences between the tribes was determined by using the student’s t-test at p≤0.05. No statistically significant differences exist between the cephalometric parameters of the tribes studied. Our findings are, therefore, consistent with the stated hypothesis.
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    Effects of Telfairia occidentalis on the haematological parameters, liver and spleen of pregnant Wistar rats
    (The Tropical Journal of Health Sciences. Published by College of Health Sciences, University of Ilorin, 2012-07) Kadir R.E.; Omotoso G.O.; Akinlolu A.A.; Enaibe B.U.; Gbenle O.B.
    Telfairia occidentalis is a dioecious perennial vine widely used for its medicinal and dietary benefits. The study was designed to evaluate the effect of T.occidentalis on haematological parameters of pregnant rats following oral administration, as well as its effects on the liver and spleen of these rats. Fifteen pregnant Wistar rats weighing between 110-130 g were used for the study. The rats were divided into 3 groups: Group A was the control, Group B was the treatment group given T. occidentalis twice daily for 4 days, while Group C received the extract twice daily for 10 days. Findings showed increase size in hepatocytes of the treated groups and increase in the trabeculae and white pulp of the treated group non-statistically significant increases The symptoms of protein energy malnutrition in haematological parameters (RBC, PCV haemoglobin level and lymphocyte count) of treated animals. These increases in blood parameters observed in this study were not as pronounced as those obtainable in non-pregnant and male rats.
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    Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
    (Research Journal of Health Sciences, 2018) Omotoso G.O.; Kadir R.E.; Lewu S.F.; Gbadamosi I.T; Akinlolu A.A.; Adunmo G.O.; Kolo R.M.; Lawal M.O; Ameen M.O.
    Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity. Keywords: demyelination, cuprizone, cerebellar damage, Moringa oleifera, oxidative enzymes
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    Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
    (College of Health Sciences, Osun State University, 2018) Omotoso G.O.; Kadir R.E.; Lewu S.F.; Gbadamosi I.T.; Akinlolu A.A.; Adunmo G.O.; Kolo R.M.; Lawal M.O.; Ameen M.O.
    Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.
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    Moringa oleifera and Musa sapientum ameliorated 7,12-Dimethylbenz[a]anthracene-induced upregulations of Ki67 and multidrug resistance 1 genes in rats
    (Qassim University, 2021) Akinlolu A.A.; Oyewopo A.O.; Kadir R.E.; Lawal A.; Ademiloye J.; Jubril A.; Ameen M.O.; Ebito G.E.
    Objectives: Moringa oleifera (MO) and Musa sapientum (MS) are plants of ethnomedicinal importance. We evaluated the effects of MOF6 (extracted from MO leaves) and MSF1 (extracted from MS suckers) on immunomodulations of Ki67 (proliferation biomarker) and multidrug resistance 1 (MDR1) genes in the liver of rats in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced hepatotoxicity and mutagenesis to determine their antiproliferation, anti-drug resistance, and anticancer potentials. Methods: Forty-five adult male rats were randomly divided into nine groups (n = 5). Groups 1 and 2 received physiological saline and 15 mg/kg bodyweight of DMBA, respectively. Groups 3 and 4 received 15 mg/kg bodyweight DMBA and were treated with 15 and 30 mg/kg bodyweight of MOF6, respectively. Group 5 received 15 mg/kg bodyweight DMBA and was treated with 10 mg/kg bodyweight of MSF1. Group 6 received 15 mg/kg bodyweight DMBA and was treated with 3.35 mg/kg bodyweight of doxorubicin and intravenous injection of 0.5 ml/200 g of cisplatin. Groups 7–9 received only 15 and 30 mg/kg bodyweight of MOF6 and 10 mg/kg bodyweight of MSF1, respectively. DMBA, doxorubicin, and extracts doses were administered orally. The duration of our experimental procedure was 8 weeks. Consequently, liver histopathology (hematoxylin and eosin technique) and enzyme-linked immunosorbent assay homogenates’ concentrations of Ki67 and MDR1 were evaluated. Computed data were statistically analyzed (P ≤ 0.05). Results: Results showed normal histoarchitectures of the liver in all groups. Statistical analyses showed significant (P ≤ 0.05) and non-significant decreased concentrations (P ≥ 0.05) of Ki67 and MDR1 in Groups 3–9 compared with Group 2. Therefore, MOF6 and MSF1 ameliorated DMBA-induced hepatotoxicity, abnormal proliferation, and drug resistance. Conclusion: MOF6 and MSF1 possess antiproliferation, anti-drug resistance, and anticancer potentials.
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    Moringa Oleifera is protective against microarchitectural and neurochemical changes associated with cuprizone-induced pre-frontal cortex neurotoxicity in female Wistar rats
    (Neuroscience Society of Nigeria, 2018) Omotoso G.O.; Gbadamosi I.T.; Akinlolu A.A.; Ameen M.O.; Kadir R.E.; Jaji-Sulaimon R.; Abdulwahab A.B.; Kolo R.M.
    Cuprizone administration causes selective damage to axonal myelin sheath and has been used to model demyelinating diseases in neuroscience research. This study aimed at determining the protective effects of Moringa oleifera on cuprizone-induced neurotoxicity in the prefrontal cortex (PFC). Sixteen adult female Wistar rats were procured and grouped into 4: Group A was given normal saline, Group B received 0.4% cuprizone diet, Group C was administered with 1.875 mg/ml of Moringa oleifera and Group D received a combination of 0.4% cuprizone diet and 1.875 mg/ml of Moringa oleifera. All the groups were treated orally for 35 consecutive days after which they were sacrificed. Thereafter the PFC was processed for histological demonstration, while tissue homogenate was used to assay the activity of superoxide dismutase (SOD). Cuprizone administration caused significant reduction in body weight and SOD activities. It also caused an alteration in the microarchitecture and Nissl profile of the PFC. Moringa oleifera intervention led to restoration of body weight, SOD levels, Nissl profile and the histology of the PFC. The use of preparations of Moringa oleifera, especially the leaf-component, could offer some protective measures to individuals suffering from demyelinating conditions, especially in addressing the associated weight changes and frontocortical dysfunction.