Browsing by Author "Akanbi II, A.A"
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Item Antibiotics Sensitivity Profile Of Proteus Species Associated With Specific Infections at University Of Ilorin Teaching Hospital, Ilorin(Published by College of Health Sciences, University of Ilorin, 2017) Giwa, A; Akanbi II, A.A; Nyamngee, A; Njan, A.A; Olubiyi, S.K; Rejuaro, F.M; Iman, S.A; Adedoja, A.AProteus is a proiitiiieni member ol llie I'amily Enterobacteriaeeae responsible for a variety ot' infections in human, such infections include urinary tract infection and many other opportunistic infections in human. The threat of antimicrobial resistance among important isolates is of great concern. This study was conducted to deteniiine the prevalence and antibiotic sensitivity pattern of Proteus spp associated with its specific infections at the University of llorin Teaching Hospital llorin. A retrospective review of cultures results of urine, wound swabs, ear and throat swabs were analysed. A total of 1,500 clinical samples were examined for identification of bacteria and their antimicrobial susceptibility. The greatest number of Proteus spp isolates were from wound swabs, 57.1%. followed by mid-stream urine 20.4%. Males were found to be more vulnerable than females in acquiring Proteus infections, 53.1% and 46.9% respectively. Results of the antimicrobial sensitivity testing showed that Imipenem and Piperacillin antibiotics were the most effective against Proteus spp with each having 100%, follow'ed by Ceftazidime 79.2%, and Ofloxacin 76.5%. The least effective antibiotic against Proteus was Augmentin 58.1% sensitivity. It is therefore recommended that Imipenem and Piperacillin should be used in the treatment of Proteus infections, and where both are not affordable. Ceftazidime and Ofloxacin could be used in the study area for the treatment of infections caused by Proteus. Regular monitoring of antimicrobial susceptibility is recommended.Item Clinical Bacterial Isolates from Hospital Environment as agent of Surgical Wound Nosocomial Infection.(Faculty of Pharmaceutical Sciences, University of Jos, 2010) Giwa, A; Attah, R.F; Ibrahim, Y.K.E; Olurinola, P.F; Akanbi II, A.A; Sanni, A.AThe relationship between bacteria isolated from the hospital environment and those from wounds of operated patients was investigated to determine the causal agents of surgical site nosocomial infections. The study was carried out on bacterial species isolated from the theatre, surgical ward and patients’ surgical wounds in a tertiary health institution in Nigeria. Bacteria were isolated from the air, floor and patients’ surgical wounds in the theatre and surgical ward by using MacConkey agar, Chocolate agar Nutrient agar and Peptone water broth as isolating media. Plasmid sizes and bands of selected twenty (20) of the isolates were determined by electrophoresis analysis to determine their relatedness. The bacterial species isolated were: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Bacillus subtilis, Bacillus cereus, Bacillus megaterium, Proteus mirabilis, Proteus vulgaris, Citrobacter freundii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Serratia marscenses. The result of electrophoresis showed that some of the isolates from the hospital environment and surgical sites have the same number of bands and molecular weight. It was concluded that isolates from the hospital environment with the same numbers of bands and molecular sizes with those isolated from patients wounds in the same hospital environment are of the same strain, and must have come from the same source, and therefore are likely to be responsible for the surgical wound infections observed in the patients studied.Item Comparative analysis of Amsel criteria and Nugent score in the Diagnosis of Bacterial vaginosis in pregnancy.(Nigerian Society for Microbiology, 2021-12) Adeniran, A.S; Ogunniran, B.D; Akanbi II, A.A; Saidu, RAbstract: The Amsel criteria and Nugent score are common diagnostic methods for BV and efforts continue to establish which method is superior. The study was a prospective cross-sectional study which compared the diagnosis of BV using the Amsel criteria and Nugent score. Participants were 316 consenting antenatal clinic attendees in the second trimester. All participants had two high vaginal swab samples collected which were analyzed using both Amsel criteria and Nugent score. Data analysis was done using SPSS version 20.0 and P<0.05 was considered statistically significant. Among the 316 study participants, the prevalence of BV was 24.1% with Nugent score and 15.5% with Amsel criteria. Also, post-treatment BV persistence rate was 25.0% with Nugent score and 11.8% with Amsel criteria. Nugent score was superior to Amsel criteria for the diagnosis of BV (χ2=74.764, P0.001). Among 76 women diagnosed BV positive by Nugent score, 36(47.4%) were diagnosed by Amsel criteria while among 240 women diagnosed BV negative with Nugent score, 14(5.8%) were diagnosed as positive by Amsel criteria. Nugent score had a higher sensitivity (93.3% vs. 80.4%), lower specificity (92.1% vs. 94.2%), higher positive (94.0% vs. 72.0%) and negative (90.0% vs. 85.0%) predictive values, lower false positive (2.0% vs. 5.8%) and false negative rate (15.0% vs. 52.6%) and higher accuracy (94.0% vs. 82.9%) compared to Amsel criteria. In conclusion, Nugent score offers an advantage over Amsel criteria in the diagnosis of BV in pregnancy, thus it should be the preferred diagnostic method