Browsing by Author "Aiyelaagbe, O. Olapeju"

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    Chemical constituents and antiproferative properties of Turraea vogelli Hook. f. ex. Benth leaves
    (The Library and Publications Committee, University of Ilorin, Nigeria, 2015-06-01) Hamid, Abdulmumeen Amao; Aiyelaagbe, O. Olapeju; Oguntoye, Stephen O.; Negi, Arvind Singh; Zubair, Marili F.
    Ethyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 ug/mL respectively. Isolation of the extracts afforded tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), Beta-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, 1D and 2D NMR and Mass Spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with 1C50 of 57.27 and 27.56 ug/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF - 7 tumor cell lines