Browsing by Author "Adunmo Godwin Olawoyin"

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    Influence of occupational cement exposure on inflammatory markers, hepatorenal function indices and oxidative stress markers among male cement handlers in Ilorin-Metropolis
    (Tanzania Journal of Health Research, 2025-04) Adunmo Godwin Olawoyin; Adeniyi Temidayo Daniel; Oyeniyi Gbadebo Maroof; Abisoye Godwin Temitope; Adunmo Eyitayo Olutoyin; Owoiya Toheeb; Osho Mercy Adeola
    Abstract Introduction: Cement dust is considered one of the most dangerous occupational hazards worldwide. Studies link cement dust exposure to respiratory disorders and cancer, but there is limited literature on its effect on inflammatory markers, hepato-renal function indices, and oxidative stress markers. This study examines how occupational exposure to cement dust affects different biochemical parameters in cement handlers in Ilorin Metropolis, an urban region in North-Central Nigeria. Methodology: A total of one hundred and twenty (120) cement handlers and sixty (60) unexposed individuals aged 25 - 60 were recruited for the study after obtaining written consent. 10 ml of fasting blood was collected and dispensed into the appropriate sample bottle. Serum levels of creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, alkaline Phosphatase (ALP) and Malondialdehyde (MDA) were measured spectrophotometrically, using commercially prepared reagents. C-reactive protein and cystatin-C levels were determined using ELISA methods. The modified diet in renal disease (MDRD) formula was utilized to calculate the estimated glomerular filtration rate (eGFR). Results: When compared with controls, the cement handlers’ sera exhibited elevated levels of Creatinine, Urea, Cystatin C, MDA, AST, ALT and C-reactive protein. Conversely, levels of albumin, total protein, and eGFR were decreased in cement handlers compared to controls. Conclusion: This study suggests that cement handlers are more susceptible to impaired kidney and liver function due to cement dust exposure. Although the exact mechanism remains unclear, increased oxidative damage and inflammation play significant roles in the observed physiological derangement. Keywords: Cement dust, C-reactive protein, cystatin-C, inflammatory markers, hepato-renal indices and oxidative stress markers
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    THERAPEUTIC EFFECT OF QUERCETIN ON THE HYPOTHALAMUS OF STZ NICOTINAMIDE INDUCED DIABETIC RATS
    (An international journal published by the Society for Experimental Biology of Nigeria, 2023-12) Lawal A.Z; Adunmo Godwin Olawoyin; Oyewopo Adeoye .; Oyewopo C .; Stephen D.; Akindehin OA; Adunfe OO; Adeleke OS; Hamzat FO; Ashamu EA
    Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and disturbances in sugar, fat, and protein metabolism. The aim of this study was to investigate the therapeutic effect of quercetin on the hypothalamus in adult male Wistar rats with STZ-nicotinamide-induced diabetes. Forty rats were divided into eight groups, each receiving different treatments. The control group received a standard diet, while other groups were administered various doses of quercetin alone, diabetes induction agents alone, or a combination of quercetin and diabetes induction agents. Treatments were administered orally for eight weeks. Results revealed significant differences in body weight among the groups, with diabetic rats showing a decrease compared to the control group. However, rats treated with quercetin or metformin exhibited a significant increase in body weight compared to the diabetic control group. Additionally, diabetes induction significantly decreased plasma insulin, plasma testosterone, follicle stimulating hormone (FSH), and luteinizing hormone levels, while quercetin treatment led to significant increases in these hormone levels. Histological examination of the hypothalamus showed notable findings. Control group rats displayed normal histomorphological features, while diabetic control rats exhibited swollen and distorted hypothalamic cells with cellular apoptosis. Interestingly, rats treated with quercetin showed a reduction in apoptotic cells, indicating a protective effect on hypothalamic cells. In conclusion, our findings suggest that quercetin possesses potential therapeutic properties in ameliorating the detrimental effects of STZ-nicotinamide-induced diabetes on the hypothalamus in adult male Wistar rats.