Influence of occupational cement exposure on inflammatory markers, hepatorenal function indices and oxidative stress markers among male cement handlers in Ilorin-Metropolis
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Date
2025-04
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Tanzania Journal of Health Research
Abstract
Abstract
Introduction: Cement dust is considered one of the most dangerous occupational hazards
worldwide. Studies link cement dust exposure to respiratory disorders and cancer, but there is
limited literature on its effect on inflammatory markers, hepato-renal function indices, and oxidative
stress markers. This study examines how occupational exposure to cement dust affects different
biochemical parameters in cement handlers in Ilorin Metropolis, an urban region in North-Central
Nigeria.
Methodology: A total of one hundred and twenty (120) cement handlers and sixty (60) unexposed
individuals aged 25 - 60 were recruited for the study after obtaining written consent. 10 ml of fasting
blood was collected and dispensed into the appropriate sample bottle. Serum levels of creatinine,
urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin,
alkaline Phosphatase (ALP) and Malondialdehyde (MDA) were measured spectrophotometrically,
using commercially prepared reagents. C-reactive protein and cystatin-C levels were determined
using ELISA methods. The modified diet in renal disease (MDRD) formula was utilized to calculate
the estimated glomerular filtration rate (eGFR).
Results: When compared with controls, the cement handlers’ sera exhibited elevated levels of
Creatinine, Urea, Cystatin C, MDA, AST, ALT and C-reactive protein. Conversely, levels of albumin,
total protein, and eGFR were decreased in cement handlers compared to controls.
Conclusion: This study suggests that cement handlers are more susceptible to impaired kidney and
liver function due to cement dust exposure. Although the exact mechanism remains unclear,
increased oxidative damage and inflammation play significant roles in the observed physiological
derangement.
Keywords: Cement dust, C-reactive protein, cystatin-C, inflammatory markers, hepato-renal indices
and oxidative stress markers
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Citation
Cement dust, C-reactive protein, cystatin-C, inflammatory markers, hepato-renal indices and oxidative stress markers