Browsing by Author "Adunmo, G.O."

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    Biochemical indices of calcium homeostasis as a biomarker of mixed toxic occupational exposure.
    (Sokoto Journal of Medical Laboratory Science, 2018-09-03) Adunmo, G.O.; Anetor, J.I.; Adesokan, A.A.; Adunmo E.O.
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    Evaluation of Ovarian Reserve in Assisted Reproductive Facilities; Biochemical and Other Alternatives: Pros and Cons-A Review Article
    (Faculty of Medical Laboratory sciences, Usmanu Danfodiyo University, Sokoto, Nigeria, 2017) Biliaminu, S.A.; Abdul Azeez, I.M.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Adunmo, G.O.
    The precarious rate of infertility has become a global issue. The social and psychological stresses attached to the problem of not having a fruit of womb have necessitated the establishment of assisted reproductive facilities within and outside Nigeria. Most of these Centers are privately owned while very few of them belonging to government. The need for the knowledge or idea of ovarian reserve in female clients of fertility centers is very crucial as it will not only tell the suitability of the client for the procedure but also assist in determining the drugs required for stimulation and the protocol required in a particular client. Various methods are being used in evaluation of ovarian reserve in assisted reproductive facilities some of which are biochemical, ultrasonographic, histopathologic and combined in nature and form. This review article is on evaluation of ovarian reserve in assisted reproductive facilities; biochemical and other alternatives as well as their pros and cons. It was essentially based on literatures and research works written in English
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    Lipid Profile as a Biomarker of Atherogenicity in Subfertile client with Hyperprolactinemia: A North- Central Nigerian University Teaching Hospital Experience.
    (Faculty of Medical Laboratory sciences, Usmanu Danfodiyo University, Sokoto, Nigeria, 2017) Abdul Azeez, I.M.; Biliaminu, S.A.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Adunmo, G.O.
    Hyperprolactinaemia is associated with amenorrhoea and decreased estrogen concentration which may lead to the elevation in total cholesterol and low density lipoprotein cholesterol (LDL-C) and decrease in high density lipoprotein cholesterol (HDL-C). The aim of this present study was to evaluate lipid profile as an artherogenic biomarker in hyperprolactinaemic sub-set of subfertile individuals. This cross-sectional study was carried among clients with hyperprolactinaemia at the Assisted Reproductive Unit of University of Ilorin Teaching Hospital, Ilorin between January and June 2015. Serum fasting total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured in 51 women with hyperprolactinaemia who were non-pregnant and not breastfeeding and 40 age-matched non- pregnant and non-breastfeeding women of child bearing age. Comparisons between serum hormonal profiles as well as lipids profiles as biomarkers of artherogenic index were assessed. Women with hyperprolactinaemia present with significantly lower serum level of FSH, progesterone and oestradiol than those of controls, while there was insignificant elevation in mean LH. There was a significant elevation in the levels of prolactin, testosterone, total cholesterol, triglycerides, HDL-C, LDL-C, mean coronary heart disease risk ratio and Castelli ratio IIin hyperprolactinaemic subjects when compared with controls. In contrast, there was no significant difference when mean values of artherogenic index and Castelli II in hyperprolactinaemic subjects were compared with those of controls. This study revealed an association between hyperprolactinaemia and dyslipidaemia with higher atherogenicity than the controls. We concluded that dyslipidaemia is common in hyperprolactinaemia and as such early lipid profile is advised as well as holistic interpretation of lipid profile as prompt treatment may prevent cardiovascular events in hyperprolactinaemic patients
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    Moringa oleifera attenuates biochemical and histological changes associated with the pancreas in nicotine-treated rats.
    (2018) Omotoso, G.O.; Adunmo, G.O.; Ojulari, L.S.; Olawuyi, T.S.; Lewu, S.F.; Jaji-Sulaimon, R.; Sulaimon, F.A.; Gbadamosi, I.T.; Onoja, P.
    Objective: The study was undertaken in order to evaluate the beneficial potential of Moringa oleifera, in nicotine-induced pancreatic injury. Method: Forty-five adult female albino rats were divided into 5 groups A-E, each group having nine rats. Group Areceived normal saline; group B received 6.88 mg/kg of nicotine intraperitoneally (i.p); group C received 6.88 mg/kg of nicotine i.p. and 200 mg/kg of Moringa oleifera leaf powder dissolved in 2 ml of normal saline (orally); group D received 13.76 mg/kg of nicotine i.p., while group E received 13.76 mg/kg of nicotine i.p. and 200 mg/kg of Moringa oleifera leaf powder dissolved in 2 ml of normal saline (orally). Treatment was for 8 days and the rats were sacrificed after 24 hours of termination of study. Intracardial blood specimens were obtained to analyse blood glucose, while the pancreas was excised and either fixed in 4% paraformaldehyde for histology or sucrose solution and homogenised for biochemical analysis of lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) enzymes. Results: In comparison with the Control, animals treated with low dose of nicotine with or without Moringa oleifera and those treated with high dose of nicotine plus Moringa oleifera had reduction in body weights (p>0.05), while marked reduction in pancreatic weights was noted in low dose nicotine (p<0.05) and both nicotine groups co-treated with Moringa oleifera (p<0.05). There were no significant changes in the levels of blood glucose and pancreatic G-6-PDH levels, while significant reduction occurred in pancreatic LDH levels in nicotine-treated rats (p<0.05). However, LDH improved following co administration with Moringa oleifera. Observation of the histology of the pancreas revealed atrophy of intercalated ducts, poorly delineated and disintegrating islet of Langerhans in animals treated with the higher dose of nicotine, while changes in pancreatic tissue in animals co-treated with Moringa oleifera were not as severe as the nicotine-treated animals. Conclusion: Moringa oleifera leaf decoction minimally ameliorates morphological and biochemical changes associated with nicotine-induced pancreatic damage.