Browsing by Author "Adeoye, Peter O"

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    Disseminated tuberculosis in a Nigerian adolescent with Linear IgA Bullous Dermatosis: A case report and review of the literature.
    (2022-06) Gobir, Aisha; Ariyibi, Solomon O; Ibraheem, Rasheedat M; Johnson, Abdul-Wahab BR; Abdulkadir, Mohammed B; Katibi, Oludolapo S; Adeoye, Peter O; Udoh, E.A; ilesanmi, Omotoyosi; Folaranmi, Olalekan.O
    Linear IgA bullous dermatosis (LABD) is an auto-immune disease affecting young children and adults, characterized by the linear deposition of IgA at the basement membrane zone with resultant complement activation and a cascade of immune reactions. There is a loss of adhesion at the dermo-epidermal junction and subsequent blister formation. It is a rare disease that has a good prognosis with adequate therapy. However, the underlying depressed immunity associated with the disease may expose them to such infections as tuberculosis. We report the case of an 11-years-old Nigerian female adolescent with LABD, diagnosed at the age of four years but defaulted on fol low-up, who developed disseminated tuberculosis (pulmonary, lymph nodes, abdominal and pericardial effusion) seven years after the appearance of the initial blistering skin lesions. She commenced anti-tuberculosis drugs, steroids, and a tube pericardiostomy for the pericardial effusion. Dapsone was initiated for the LABD during the continuation phase of anti-tuberculosis therapy, with subsequent disappearance of the skin rash within two weeks. WAJM 2022; 39(6): 646– 650.