Browsing by Author "Adeniran S. Adekunle"

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    Abstracts Presented at the 16th Conference of the Neuroscience Society of Nigeria Prosopis africana seeds aqueous extract modulates brain and serum lipid profiles of female Wistar...
    (Nig. J. Neurosci., 2019) Abdulrahim Halimat A.; Adeniran S. Adekunle; Adesola I. R. Abioye; Abdulrazaq B. Nafiu; Abdul-rahuf A. Feyitimi; Noah A. Omeiza; Benedict B. Siaka; Tavershima M. Ateh
    Lipid profile and atherogenic index have been shown to be substantial predictors for metabolic disturbances and challenges such as cost and adverse effects make investigation on plants and their bioactive components indispensable. This study seeks to evaluate the pharmacological potential of Prosopis Africana (PA) seeds aqueous extract on lipid metabolism in female Wistar rats. The rats (200-230g; n=10) were exposed to PA at varying doses (500 mg/kg b.w., p.o) or (1000 mg/kg b.w., p.o) once per day for thirty days. Control animals (n=5) were exposed to 0.2 ml/kg b.w/day physiological saline for the same period via intragastric gavages. Blood and brain tissue supernatants were collected for biochemical assays. The result showed a significant (p<0.05) influences of PA on total cholesterol, low density lipoprotein, high density lipoprotein concentrations in both serum and brain tissue; cardiovascular risk ratios and atherogenic index were being raised when com- pare PA-treated to control. Meanwhile, PA at 500 and 1000 mg/kg showed insignificant (p˃0.05) decrease in serum triglycerides and very low density lipoprotein. These findings indicate that both PA regimen potentially increased serum lipids (TC and LDL-C) along with reduced HDL-C reflecting the characteristic dyslipidemic effect and their vascular hemodynamic disturbances which may favour plaque formation and promotes risk of atherosclerosis. Furthermore, PA dosages in brain homogenates modulate the lipid concentration (lowers TC and LDL-C, increases TG and HDL-C). Aqueous extract PA seeds enhanced transport of cholesterol from nervous tissues to the liver for further metabolic needs. Therefore PA possessed cardioprotective and neuroprotective properties.
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    Phytochemical Analyses, Antimicrobial Activities and Possible Antimicrobial Mechanism of Adansonia Digitata: An Animal Model
    (Alexandria Journal of Veterinary Sciences, 2022-07-01) Olutoyin C. Adekunle; Temitope I. Adelusi; Ismaila O. Sule; Akanmidu R. Olorunfemi; Abdulrahim Halimat A.; Adeniran S. Adekunle
    The advent of antibiotics recorded a huge amount of success against disease- causing microbes. However, development of resistance to reference antibiotics leading to increased mortality have caused critical concern in the management of infectious diseases. Continuous search for alternative therapies has shown good candidates in medicinal plants, although without thorough examination of possible mechanism of action. This study assessed the phytochemical constituents, antimicrobial activities, and possible antimicrobial mechanism of Adansonia digitata, against Shigella flexneri, Escerichia Coli and Salmonella enteritis. Phytochemical analyses showed that Adansonia digitata is rich phytosterols, flavonoids, phenolics and carotenoids. Assessments of antimicrobial activities of A. digitata revealed its effectiveness against S. flexneri, E. coli and S. enteritis. The mechanism of antimicrobial activities of A. digitata may involve inhibition of Gram+ and Gram- transpeptidase and dihydrofolate reductase. The antimicrobial activities may be ascribed to the presence of phytochemicals in A. digitata.