Abstracts Presented at the 16th Conference of the Neuroscience Society of Nigeria Prosopis africana seeds aqueous extract modulates brain and serum lipid profiles of female Wistar...
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Date
2019
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Nig. J. Neurosci.
Abstract
Lipid profile and atherogenic index have been
shown to be substantial predictors for metabolic
disturbances and challenges such as cost and
adverse effects make investigation on plants and
their bioactive components indispensable. This
study seeks to evaluate the pharmacological
potential of Prosopis Africana (PA) seeds
aqueous extract on lipid metabolism in female
Wistar rats. The rats (200-230g; n=10) were
exposed to PA at varying doses (500 mg/kg b.w.,
p.o) or (1000 mg/kg b.w., p.o) once per day for
thirty days. Control animals (n=5) were exposed
to 0.2 ml/kg b.w/day physiological saline for the
same period via intragastric gavages. Blood and
brain tissue supernatants were collected for
biochemical assays. The result showed a
significant (p<0.05) influences of PA on total
cholesterol, low density lipoprotein, high density
lipoprotein concentrations in both serum and
brain tissue; cardiovascular risk ratios and
atherogenic index were being raised when com-
pare PA-treated to control. Meanwhile, PA at 500
and 1000 mg/kg showed insignificant (p˃0.05)
decrease in serum triglycerides and very low
density lipoprotein. These findings indicate that
both PA regimen potentially increased serum
lipids (TC and LDL-C) along with reduced HDL-C
reflecting the characteristic dyslipidemic effect
and their vascular hemodynamic disturbances
which may favour plaque formation and
promotes risk of atherosclerosis. Furthermore,
PA dosages in brain homogenates modulate the
lipid concentration (lowers TC and LDL-C,
increases TG and HDL-C). Aqueous extract PA
seeds enhanced transport of cholesterol from
nervous tissues to the liver for further metabolic
needs. Therefore PA possessed cardioprotective
and neuroprotective properties.
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words: Prosopis africana, Lipid profile, Lipid indices, Dyslipidemia, Atherosclerosis