Browsing by Author "Adegoke, O. A."

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    Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats
    (Published by University of Ilorin, Ilorin, Nigeria, 2012) Ojulari, L. S.; Biliaminu, S. A.; Dangana, E. O.; Abdulazeez, F. I.; Ayinde, T. O.; Adegoke, O. A.
    global health. It contributes to oxidative stress and also induces inflammation and hence severe complications. Several drugs have been introduced so far to salvage this metabolic disease alongside its complications. Objectives: This study was designed to investigate the effects of gliclazide on serum uric acid and C-reactive protein (a biomarker of inflammation) in alloxan-induced diabetic rats. Materials and Methods: Sixteen wistar rats were divided into 4 experimental groups with four rats each; Group A-control (Drug vehicle), Group B-diabetic, Group C- diabetic/gliclazide (10mg/kg twice daily for 28days) and Group D-normal/gliclazide (10mg/kg twice daily for 28 days). At the end of the experimental period (four weeks), animals in all groups were fasted for 12 hours and blood samples were taken by cardiac puncture for determination of serum uric acid and C-reactive protein (CRP) levels. Results: The study shows no significant statistical change in the serum uric acid levels (p>0.05) when the Experimental groups were compared with the controls. On the other hand, there was significant decrease (p<0.05) in CRP levels when values in the controls were compared with diabetic treated and normal treated groups. Conclusion: This finding may suggests that gliclazide possesses cardioprotective property since CRP has been implicated in atherosclerotic changes which is a common complication of diabetes mellitus. This may be through its anti-inflammatory effect by reducing the plasma concentration of IL-6, which is produced predominantly by macrophages and so prevents diabetic complications.
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    The Effect of Metformin on Serum Levels of FSH, LH, Oestrogen and Progesterone in Diabetic Rats
    (College of Health Sciences, University of Ilorin, Ilorin, Nigeria, 2013) Ojulari, L. S.; Biliaminu, S. A.; Ahmed, T. T.; Abdulazeez, F. I.; Oyekunle, O. F.; Niyi-Odumosu, F. A.; Adegoke, O. A.
    Diabetes mellitus represents one of the greatest global health threats. It contributes to sub-fertility in females and impairs the normal menstrual cycle and ovulation. This study was designed to investigate the effect of oral administration of metformin on FSH, LH, oestrogen, and progesterone in diabetic rats. Twenty female rats were divided into four experimental groups of five rats each. Group A (control) received distilled water ad libitum. Group B were diabetic untreated; Group C received metformin only; Group D were diabetic and received metformin. At the end of the four-week treatment period, blood samples were collected for hormone assays. The results showed significant (P<0.05) reductions in FSH and LH levels in all experimental groups compared to control. Progesterone levels significantly increased in Groups B and D compared to control, while oestrogen levels were reduced in all experimental groups but insignificantly (P>0.05). The study suggests that metformin’s ovulation-inducing effect is likely due to its direct action on the ovary, and not solely due to improved insulin sensitivity.