Browsing by Author "Abdullahi, A. A."

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    ANTI-INFLAMMATORY AND ANALGESIC POTENTIALS OF THE ROOT BARK EXTRACT OF SABA COMORENSIS (BOJER) PICHON (APOCYNACEAE) USED IN NIGERIAN TRADITIONAL MEDICINE
    (Nigerian Journal of Pharmaceutical Sciences, 2020-03) Attah, F. A; Chukwudulue, U. M.; Diyaolu, O. A.; Njinga, N. S.; Abdullahi, A. A.; Agunu, A.; Musa, K. Y.
    Painful and inflammatory diseases such as arthritis, backache, headaches, asthma and peptic ulcer disease are widespread and highly prevalent. The existing drugs for these conditions are liable to sub-optimal efficacy, intolerable adverse effects, prohibitive costs or limited availability. This scenario calls for renewed search for additional anti-inflammatory and analgesic agents. Hence, in line with the Traditional uses of plants, this study investigated the ethanol extract of Saba comorensis (Bojer ex. A.DC.) Pichon, for its safety, anti-inflammatory and analgesic effects in rodents using standard experimental protocols. The LD50 (i.p.) for the ethanol extract obtained from the geometric mean of doses was 770 mg/kg. Compared with the negative controls, the ethanol extract exhibited significant (p<0.05) and dose-dependent anti-inflammatory, ulcerogenic and dose-independent analgesic effects, while the petroleum extract did not induce any significant ulcerogenic effects. These findings suggest Saba comorensis ethanol root extract may be relatively safe and possesses anti-inflammatory and analgesic properties and may justify its use as traditional remedy for painful and inflammatory conditions. There is the need to investigate the study plant further for anti-inflammatory and analgesic drug discovery
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    Epipremnum aureum (Linden and André) G. S. Bunting (Araceae): Free Radicals Scavenging, Cell Growth Inhibition and Cytotoxic effects on Rhabdomyosarcoma and Laryngeal Carcinoma Cancer Cells
    (Pharmaceutical Journal of Kenya, 2023) Salawu, K. M.; Ogbole, O. O.; Mohammed, A.; Abdullahi, A. A.; Ajaiyeoba, E. O.
    Patients with chronic health conditions such as cancer often benefit from plant based herbal recipes with minimal adverse effects. There also exists growing worries over the safety and efficacy of most of the currently used conventional chemotherapeutic agents. This study examined the radical scavenging and cytotoxicity of E. aureum traditionally employed for the management of cancerous diseases. The aerial part of Epipremnum aureum was collected from the University of Ibadan botanical garden and authenticated at the Forest Herbarium Ibadan. Air-dried aerial part of Epipremnum aureum was pulverized and extracted with 70% aq. methanol and concentrated in vacuo. A portion the methanol extract was fractionated and crude alkaloidal extract was prepared from another portion of the methanol extract. The extracts and fractions were subjected to; antioxidant DPPH radical scavenging assay and cytotoxicity of the extracts and fractions against rhabdomyosarcoma (Rd) and laryngeal carcinoma (Hep-2C) cancer and non-cancerous (Vero) cell lines were determined. Ethyl acetate fraction and alkaloidal extract displayed better DPPH radical scavenging activity than the methanol extract and other fractions. The alkaloidal extract (CC50=0.17±0.03μg/mL) and dichloromethane fraction (CC50=0.28±0.05 μg/mL) displayed the highest cytotoxicity against Rd cancer cell lines compared to cyclophosphamide (CC50=2.23±0.33 μg/mL). However, the alkaloidal extract displayed the least cytotoxicity to Vero cell line and it is about 14.25 and 22.18 times more cytotoxic to Rd and Hep-2C cancer cells, respectively. Key words: Radical Scavenging, Cytotoxicity, GC-MS Analysis, Epipremnum aureum