Browsing by Author "Abdul-Olumoh, H.A"
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Item ACUTE AND SUBACUTE TOXICITY STUDIES ON METHANOL LEAF EXTRACT OF TURRAEA VOGELII HOOK. F. EX. BENTH.(Faculty of Pharmaceutical Sciences Ahmadu Bello University Zaria, 2018) Ayanniyi, R.O; Abdul-Olumoh, H.A; Ojuade, F.I; Adebisi-jose, G.O; Rasheed, M.WIn Africa, majority of people rely on medicinal plants for their health care needs as well as for food. There are numerous scientific reports on efficacy of medicinal plants, with limited reports on the safety of these plants. Turraea vogelii Hook. f. ex. Benth. is an ethno medicinal plant indigenous to Tropical Africa. It is used as food, drinks and widely explored in ethno medicine for treatment of various ailments including; wounds, stomach ache, malaria fever, intestinal worms and urogenital infections. The aim of this study was to evaluate the acute and subacute oral toxicity of methanol leaf extract of T. vogelii in experimental animals. Acute oral toxicity was determined following OECD guideline 423. Doses of 125, 250, 500 mg/kg were administered for 28 days in the subacute oral toxicity study. Effect of extract on haematological parameters, liver and kidney function markers were determined. The acute oral toxicity of Turraea vogelii was estimated to be greater than 2000mg/kg. The extract had no significant effect on haematological parameters, liver and renal function parameters when compared with the control. The extract however produced inflammatory changes and alterations in morphology of the liver. The results from this study shows that the methanol leaf extract of Turraea vogelii produced toxic effects on the liver when repeated oral doses were administered.Item Evaluation of Diuretic activity of Methanol Leaf Extract of Clerodendrum volubile(Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka., 2022) Aiyelero, O.M.; Ojuade, F.I.; Abdul-Olumoh, H.A; Ibegbunan, C.O.; Ayanniyi, R.O.Clerodendrum volubile is used for the local management of fluid retention or edema. This present study aimed to evaluate the diuretic activity of the methanol leaf extract of Clerodendrum volubile, (MCV) family - Labiatae on experimental animals at 200-800 mg/kg body weight respectively. The animals were observed for different indicators of diuresis such as volume, electrolyte concentration, and pH of urine for 5 hours using standard methods. Methanol leaf extract of Clerodendrum volubile (MCV) induced diuresis and produced a non-significant increase (p<0.05) in urine output when compared to the negative control group. The 200 mg/kg dose of MCV produced the highest volume. In addition, the extract produced non-significant increase in the saliuretic and natriuretic activity when compared with furosemide 10 mg/kg. MCV may still be considered to have favorable natriuretic effects since the computed values were above 2.0 which is the benchmark for natriuretic effects. From this study, it can be inferred that MCV may have diuretic activity thus justifying its ethnomedicinal use in the management of fluid over load.