Evaluation of Diuretic activity of Methanol Leaf Extract of Clerodendrum volubile
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Date
2022
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Journal ISSN
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Publisher
Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Abstract
Clerodendrum volubile is used for the local management of fluid retention or edema. This present study aimed to
evaluate the diuretic activity of the methanol leaf extract of Clerodendrum volubile, (MCV) family - Labiatae on
experimental animals at 200-800 mg/kg body weight respectively. The animals were observed for different
indicators of diuresis such as volume, electrolyte concentration, and pH of urine for 5 hours using standard
methods. Methanol leaf extract of Clerodendrum volubile (MCV) induced diuresis and produced a non-significant
increase (p<0.05) in urine output when compared to the negative control group. The 200 mg/kg dose of MCV
produced the highest volume. In addition, the extract produced non-significant increase in the saliuretic and
natriuretic activity when compared with furosemide 10 mg/kg. MCV may still be considered to have favorable
natriuretic effects since the computed values were above 2.0 which is the benchmark for natriuretic effects. From
this study, it can be inferred that MCV may have diuretic activity thus justifying its ethnomedicinal use in the
management of fluid over load.
Description
Keywords
Clerodendrum volubile; Leaf; Diuretic; Saliuretic; Rats.