Browsing by Author "Abdul Azeez, I.M."
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Item Biochemical Infertility Among Prospective Oocyte Donors at the University of Ilorin Teaching Hospital Assisted Reproductive Unit, Nigeria(College of Health Sciences, University of Ilorin, 2018) Biliaminu, S.A.; Abdul Azeez, I.M.; Akande, A.A.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.Item Evaluation of Ovarian Reserve in Assisted Reproductive Facilities; Biochemical and Other Alternatives: Pros and Cons-A Review Article(Faculty of Medical Laboratory sciences, Usmanu Danfodiyo University, Sokoto, Nigeria, 2017) Biliaminu, S.A.; Abdul Azeez, I.M.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Adunmo, G.O.The precarious rate of infertility has become a global issue. The social and psychological stresses attached to the problem of not having a fruit of womb have necessitated the establishment of assisted reproductive facilities within and outside Nigeria. Most of these Centers are privately owned while very few of them belonging to government. The need for the knowledge or idea of ovarian reserve in female clients of fertility centers is very crucial as it will not only tell the suitability of the client for the procedure but also assist in determining the drugs required for stimulation and the protocol required in a particular client. Various methods are being used in evaluation of ovarian reserve in assisted reproductive facilities some of which are biochemical, ultrasonographic, histopathologic and combined in nature and form. This review article is on evaluation of ovarian reserve in assisted reproductive facilities; biochemical and other alternatives as well as their pros and cons. It was essentially based on literatures and research works written in EnglishItem Lipid Profile as a Biomarker of Atherogenicity in Subfertile client with Hyperprolactinemia: A North- Central Nigerian University Teaching Hospital Experience.(Faculty of Medical Laboratory sciences, Usmanu Danfodiyo University, Sokoto, Nigeria, 2017) Abdul Azeez, I.M.; Biliaminu, S.A.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Adunmo, G.O.Hyperprolactinaemia is associated with amenorrhoea and decreased estrogen concentration which may lead to the elevation in total cholesterol and low density lipoprotein cholesterol (LDL-C) and decrease in high density lipoprotein cholesterol (HDL-C). The aim of this present study was to evaluate lipid profile as an artherogenic biomarker in hyperprolactinaemic sub-set of subfertile individuals. This cross-sectional study was carried among clients with hyperprolactinaemia at the Assisted Reproductive Unit of University of Ilorin Teaching Hospital, Ilorin between January and June 2015. Serum fasting total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured in 51 women with hyperprolactinaemia who were non-pregnant and not breastfeeding and 40 age-matched non- pregnant and non-breastfeeding women of child bearing age. Comparisons between serum hormonal profiles as well as lipids profiles as biomarkers of artherogenic index were assessed. Women with hyperprolactinaemia present with significantly lower serum level of FSH, progesterone and oestradiol than those of controls, while there was insignificant elevation in mean LH. There was a significant elevation in the levels of prolactin, testosterone, total cholesterol, triglycerides, HDL-C, LDL-C, mean coronary heart disease risk ratio and Castelli ratio IIin hyperprolactinaemic subjects when compared with controls. In contrast, there was no significant difference when mean values of artherogenic index and Castelli II in hyperprolactinaemic subjects were compared with those of controls. This study revealed an association between hyperprolactinaemia and dyslipidaemia with higher atherogenicity than the controls. We concluded that dyslipidaemia is common in hyperprolactinaemia and as such early lipid profile is advised as well as holistic interpretation of lipid profile as prompt treatment may prevent cardiovascular events in hyperprolactinaemic patientsItem Lipid profile in subfertile clients with premature ovarian failure: University of Ilorin Teaching Hospital(Krishna Institute of Medical Sciences, 2018) Abdul Azeez, I.M.; Biliaminu, S.A.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.Background: Premature Ovarian Failure (POF) is associated with a higher incidence of cardiovascular events later in life. Concurrent with the ages of menopausal transition, a shift in lipid profile takes place. The increased burden may be mediated by a worsening of cardiovascular risk factors, such as lipids, corresponding with the loss of ovarian function. Aim and Objectives: To investigate serum lipid and hormonal levels in women with premature ovarian failure and compare with those of apparently healthy women of similar age. Material and Methods: The study was a cross-sectional one in which serum fasting Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C) and Low Density Lipoprotein Cholesterol (LDL-C) levels were measured in 50 women with POF and compared with 40 age matched control. Serum hormonal profiles were compared with lipid profiles and biomarkers of atherogenic index were assessed. Results:Women with POF present with statistically significant elevations in the mean values of serum FSH and LH, when compared with those of controls (p<0.001), while there were significant decrease in mean levels of serum prolactin, progesterone, testosterone and oestradiol when subjects were compared with controls (p<0.001). There were statistically significant elevations in serum total cholesterol, triglycerides, HDL-C and LDL-C, in premature ovarian failure subjects when compared with controls (p<0.001). There was statistically significantly difference when mean values of artherogenic index and Castelli ratio II of subjects were compared with those of controls. Conclusion: Loss of ovarian function at a very young age (POF) was characterized with subtle changesin the serum lipid profile (higher TC, TG, HDL-C, and LDL-C levels). It also shows that atherogenic index and Castelli ratio II are better tools for assessment of atherogenicity than CHD risk ratio and Castelli ratio I in patients with POF.Item Non-galactorrheic hyperprolactinaemia in subfertile female patients: A Nigerian tertiary Hospital experience(College of Health Sciences, University of Ilorin, 2017) Biliaminu, S.A.; Abdul Azeez, I.M.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Ishola, F.; Abdul Azeez, I.F.