Browsing by Author "AYANNIYI, Rashidat Oluwafunke"
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Item Evaluation of heavy metal and microbial content of a multicomponent herbal preparation(Faculty of Pharmaceutical Sciences, University of Jos, Jos, 2021-01) OLUMOH-ABDUL, Hidayah Ayodeji; AYANNIYI, Rashidat Oluwafunke; OJUADE, Fatimoh Idowu; OLUFADI-AHMED, Haishat Yetunde; ONIBON, Zainab OluwatosinHerbal mixtures are extensively consumed globally for medicinal use due to the belief that they are safe and readily accessible. The herbal preparation (SHM), evaluated in this study, is made up of 7 plants found in Nigeria and it is used internally and externally for varieties of disease conditions. The heavy metals and microbial content of SHM was evaluated. Three batches of the SMH were analyzed for presence of heavy metals using Atomic Absorption Spectrophotometer. The microbial load was also evaluated by determining the total viable yeast, mould and coliform bacteria count. The metal and microbial content of the samples were compared with WHO permissible limits and differences in concentration among the batches were determined. Fe (0.010-0.100 mg/L) and Zn (0.010-0.030 mg/L) detected were significantly (P<0.05) lower than the permissible limits while Cu, Pb and Cd were absent. A batch had total yeast and mould count (4.95 x 103Cfu/mL) above the permissible limit whereas the other batches were below the limit. Microorganisms (yeasts, mould like Aspergillus flavus and Rhizoctonia solani) were present in all the batches and hence SHM may not be safe for internal use.Item Evaluation of Nutraceutical content and topical Anti-inflammatory Activities of Turraea vogelii Hook F. Ex Benth (Meliaceae)(Arak University of Medical Sciences, 2019-02) ABDUL-OLUMOH, HIDAYAH AYODEJI; AYANNIYI, Rashidat Oluwafunke; OJUADE, FATIMOH IDOWU; AGBANA, REMILEKUN JUSTINABackground: Turraea vogelii has been used as traditional medicine for the treatment of ailments including wounds, stomach aches, malaria, infections, filariasis cutaneous, among others and, it serves as source of food. The present study aimed to evaluate the nutraceuticals content and topical anti-inflammatory effect of hydro-methanol twig extract of Turraea vogelii (METV). Method: METV was obtained using cold maceration with water and methanol in ratio 30:70. The concentration of vitamins A, C and E, total phenolic and total flavonoid contents were evaluated by UV spectrophotometric method. Phenol and xylene-induced ear edema was used to evaluate the topical anti-inflammatory effect in mice. Results: The concentration of vitamins A, C and E was found to be 0.113 0.006, 9.303 0.012 and 0.020 0.001 mg in 100g of dried plant materials, respectively. Total phenolic and flavonoid contents were 0.281 0.318 mg/g gallic acid equivalent and 0.112 mg/g quercetin equivalent, respectively. Topical application of METV at a dose of 25 and 50mg/ear in xylene-induced ear edema produced significant inhibition (P<0.05) of 33 and 54% while in phenol-induced ear edema was significantly (P< 0.05) reduced by 44% and 34%. Dexamethasone (0.1mg/ear) produced an inhibition of 83% and 57% in phenol-induced ear edema. Conclusion: Results from this study demonstrated that Turraea vogelii twigs contain flavonoids and phenolic compounds, which may be responsible for the topical anti-inflammatory effect of the plant extract.Item GASTRO-PROTECTIVE ACTIVITY OF TURRAEA VOGELII LEAF EXTRACT AGAINST INFLAMMATION INDUCED BY DICLOFENAC(Faculty Of Pharmaceutical Sciences University of Nigeria Nsukka, 2021) AYANNIYI, Rashidat Oluwafunke; JOSHUA, EMMANUEL OMEIZA; OLUMOH-ABDUL, HIDAYAH AYODEJI; OJUADE, FATIMOH IDOWUTurraea vogelii Hook f. ex. Benth (Meliaceae) is used in traditional medicine for treatment of gastrointestinal disorders, wounds and infections. The protective effect of methanol leaf extract of Turraea vogelii (T. vogelii) on gastric inflammation induced by diclofenac was investigated. Rats were treated orally with 200 and 400 mg/kg T. vogelii before and after administration of diclofenac (150 mg/kg). Three hours after treatment, animals were anaesthetized with intraperitoneal injection of ketamine (60 mg/kg) and xylazine (7.5 mg/kg). The stomachs were removed for macroscopic examination. The stomach of rats treated with diclofenac showed significant redness, hemorrhagic streak and bands of inflammation. Methanol leaf extract of T. vogelii (200-400 mg/kg) significantly (p<0.0001) inhibited gastric inflammation induced by diclofenac. Percentage inhibition of gastric inflammation during pretreatment with T. vogelii (200 and 400 mg/kg) was 77.69 % and 83.67 % while inhibition of inflammation with treatment was 86.83 % and 93.66 % respectively. T. vogelii leaf extract was found to have potential gastro protective activity on inflammation induced by diclofenac.