GASTRO-PROTECTIVE ACTIVITY OF TURRAEA VOGELII LEAF EXTRACT AGAINST INFLAMMATION INDUCED BY DICLOFENAC
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Date
2021
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Faculty Of Pharmaceutical Sciences University of Nigeria Nsukka
Abstract
Turraea vogelii Hook f. ex. Benth (Meliaceae) is used in traditional medicine for treatment of gastrointestinal disorders, wounds and infections. The protective effect of methanol leaf extract of Turraea vogelii (T. vogelii) on gastric inflammation induced by diclofenac was investigated. Rats were treated orally with 200 and 400 mg/kg T. vogelii before and after administration of diclofenac (150 mg/kg). Three hours after treatment, animals were anaesthetized with intraperitoneal injection of ketamine (60 mg/kg) and xylazine (7.5 mg/kg). The stomachs were removed for macroscopic examination. The stomach of rats treated with diclofenac showed significant redness, hemorrhagic streak and bands of inflammation. Methanol leaf extract of T. vogelii (200-400 mg/kg) significantly (p<0.0001) inhibited gastric inflammation induced by diclofenac. Percentage inhibition of gastric inflammation during pretreatment with T. vogelii (200 and 400 mg/kg) was 77.69 % and 83.67 % while inhibition of inflammation with treatment was 86.83 % and 93.66 % respectively. T. vogelii leaf extract was found to have potential gastro protective activity on inflammation induced by diclofenac.
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Keywords
Turraea vogelii; Leaf extract; Gastro-protective; Acute inflammation; Diclofenac.