Browsing by Author "ADAMU, S."

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    Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide- induced anaemia in rats
    (DE GRUYTER, 2020-05-15) ATATA, J.A.; AYOOLA, T.O.; AJADI, A.A.; ADAMU, S.; OLATUNJI, A.O.; BIOBAKU, K.T.
    Background: The folkloric claim that Cnidoscolus aconiti- folius (Chaya) could ameliorate anaemia requires scientific revalidation in anaemic models. Objective: The aim of this study is to investigate the anti- anaemic effect of Cnidoscolus aconitifolius on cyclophos- phamide-induced anaemia in rats. Methods: The leaves of Cnidoscolus aconitifolius were collected, dried and extracted with ethanol. Twenty five Wistar Albino rats weighing 120–180 kg were used. Anaemia was induced in groups 2, 3, 4 and 5 with a single injection of cyclophosphamide, while group 1 served as a negative control without anemia and was treated with 0.5 mL of normal saline, Group 2 rats were treated with 100 mg/kg body weight of Cnidoscolus aconitifolius. Group 3 rats were treated with 500 mg/kg body weight of Cnido- scolus aconitifolius. Group 4 served as the positive control rats and was treated with 0.5 mL of normal saline. Group 5 which served as the standard control rats and were treated with 5 mg/kg body weight of standard drug Chemiron. The treated lasted for two weeks during which blood samples were collected from each rat for haematological analysis. Results: The result shows that hematological parame- ters were elevated in groups 2, 3 and 5 rats treated with 100 mg/kg and 500 mg/kg body weight of ethanol extract of Cnidoscolus aconitifolius and chemiron respectively. Conclusions: Ethanol leaf extract of Cnidoscolus aconiti- folius at a graded dose of 500 mg/kg body weight had higher ameliorative effect on the haematological parame- ters of cyclophosphamide-induced anemia in rats.
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    Haemato-biochemical studies of dogs with haemorrhage-induced dehydration
    (Springer Nature, 2018-08-15) ATATA, A.A.; ESIEVO, K.A.AN.; ADAMU, S.; ABDULSALAM, H.; AVAZI, D.O.; AJADI, A.A.
    Factors that contribute to water loss in tropical animals are complex and constantly changing. To evaluate the haemato- biochemical parameters of dogs with haemorrhage-induced dehydration. A total of 12 dogs were used; haemorrhage was induced by daily removal of 10 ml of blood over a period of 28 days and analysed at the Department of Veterinary Pathology, Ahmadu Bello University (A.B.U.), Zaria, Nigeria. Dehydration was clinically assessed. Age, sex, body weight and generalised body condition of the animals were determined. Whole blood was collected for determination of haematological parameters. Serum was prepared from whole blood to determine the concentrations of urea, creatinine, total protein, albumin, glucose, sodium, calcium, chloride, phosphorus, potassium, bicarbonate, blood urea nitrogen (BUN)/creatinine ratio and anion gap (AG) as well as serum activities of liver enzymes. Reductions in body weight (1.67 kg, 2.17 kg and 3.17 kg) due to degrees of dehydration were observed on days 14, 21 and 28. Significantly higher values of packed cell volume and haemoglobin concentration (P < 0.01) due to dehydration was observed between days 0 and 14, also between days 0 and 28. Higher concentrations of urea, creatinine (P < 0.01), BUN/creatinine, total protein, albumin and urine specific gravity (P < 0.05) were observed between day 0 and days 14, 21 and 28. This study is the first to report the haemato-biochemical changes of Nigerian local dogs with haemorrhage-induced dehydration. The study did not investigate the role of type of diet on dehydration, and it is recommended that future studies should be carried out to elucidate this.