Memory, neurogenic protein and oxidative deficits of frontal cortex following chlorpyrifos/dichlorvos exposure in rats
No Thumbnail Available
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
College of Health Sciences, Osun State University, Nigeria
Abstract
Objective: The use of xenobiotics to boost agricultural productivity has led to toxic chemicals exposure
including organophosphates, causing adverse health outcomes including behavioral and neuronal
impairments. This study aimed to evaluate the memory indices, possible oxidative and cholinesterase outturns
on the frontal cortices of rats exposed to organophosphates.
Methodology: Thirty-two Wistar rats were grouped into four. They received 1ml/kg of Normal, 8.8
mg/kg dichlorvos, 14.9 mg/kg chlopyrifos, and 8.8 mg/kg dichlorvos plus 14.9mg/kg chlorpyrifos
respectively. They had training trials in the Y Maze paradigm then spatial working memory assessment.
They were euthanized 24hours following exposure and tissues excised for analysis.
Results: A marked reduction in metabolic markers, Acetylcholine Esterase (AChE) activity, spatial
memory indices and proliferative neuron marker (Ki67) were observed. Also, increase in oxidative stress
markers in the frontal cortices of the organophosphates exposed rats.
Conclusion: The findings demonstrated neurotoxic effects of organophosphates in rats.
Description
Keywords
Organophosphates, Oxidative stress, Acetylcholinesterase, Spatial memory
Citation
16. Kadir R.E., Gegele T.A. , Kola-Taiwo I.O. , Oyewole A.L. , Ibrahim A. , Imam A, Chengetanai S. , Ajao M.S. (2022). Memory, neurogenic protein and oxidative deficits of frontal cortex following chlorpyrifos/dichlorvos exposure in rats. Research Journal of Health Sciences. 10(2):101-111. Published by College of Health Sciences, Osun State University, Nigeria. Available online at https://www.ajol.info/index.php/rejhs/issue/view/20677