Inhibitory properties of Bambara groundnut protein hydrolysate and peptide fractions against angiotensin converting enzymes, rennin and free radicals

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dc.contributor.authorArise, A.K
dc.contributor.authorAlashi, A.M
dc.contributor.authorNwachukwu, I.D
dc.contributor.authorMalomo, S.A.
dc.contributor.authorAluko, R.E
dc.contributor.authorAmonsou, E.O
dc.date.accessioned2018-12-18T14:04:04Z
dc.date.available2018-12-18T14:04:04Z
dc.date.issued2016
dc.description.abstractBACKGROUND:Anincreasedrateofhighbloodpressurehasledtocriticalhumanhypertensiveconditionsinmostnations.Inthepresentstudy,bambaraproteinhydrolysates(BPHs)obtainedusingthreedifferentproteases(alcalase,trypsinandpepsin)and theirpeptidefractions(molecularweight:10,5,3and1kDa)wereinvestigatedforantihypertensiveandantioxidantactivities. RESULTS:Alcalasehydrolysatecontainedthehighestamountoflowmolecularweight(LMW)peptidescomparedtopepsinand trypsinhydrolysates.LMWpeptidesfractions(<1kDa)exhibitedthehighestinhibitoryactivityagainstangiotensin-converting enzyme (ACE) for all the enzymes hydrolysates. For renin inhibition, alcalase hydrolysate showed the highest inhibition at 59%comparedtootherhydrolysatesandtheircorrespondingmembranefractions.Theantioxidantpowerofbambaraprotein hydrolysates and peptide fractions was evaluated through the inhibition of linoleic acid peroxidation and ABTS scavenging activity.Amongthehydrolysates,alcalaseexhibitedthehighestinhibitionoflinoleicacidoxidation.Furthermore,allBPHswere abletoscavengeABTS•+ to a three fold greater extent compared to the isolate. CONCLUSION: BPH and LMW peptide fractions could potentially serve as useful ingredients in the formulation of functional foods and nutraceuticals against high blood pressure and oxidative stressen_US
dc.identifier.urihttp://hdl.handle.net/123456789/1445
dc.language.isoenen_US
dc.publisherPublished by Society of Chemical Industryen_US
dc.subjectBambaraen_US
dc.subjectProtein hydrolysateen_US
dc.subjectReninen_US
dc.subjectMembrane ultrafiltrationen_US
dc.subjectangiotensin-converting enzymeen_US
dc.subjectantioxidant activityen_US
dc.titleInhibitory properties of Bambara groundnut protein hydrolysate and peptide fractions against angiotensin converting enzymes, rennin and free radicalsen_US
dc.typeArticleen_US

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