Phytochemical, Analgesic and Anti-inflammatory Analysis of the Ethyl acetate Fraction of Paullinia pinata Leaf L. (Sapindaceae).
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Date
2018
Journal Title
Journal ISSN
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Publisher
Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin.
Abstract
Paullinia pinnata(Sapindaceae) is commonly called sweet gum (English). Traditionally various
parts of P. pinnata is used in the management of various diseases including chronic arthritis
rheumatic pain. Phytochemical investigation of the ethyl acetate fraction of P. Pinnata leaf
showed the presence of flavonoids, saponins, anthraquinone, steroidal terpenoids and
carbohydrates only and it was also observed to be non-toxic with LD50 of 1264.9 mg/kg. The
fraction displayed significant analgesic activity (21.45, 35.62 and 92.70 % inhibition at 75, 150
and 300 mg/kg body weight respectively) in the formalin induced pain model, whereas
ketoprofen had a 28.32 % inhibition of pain. In acetic acid induced writhing model the fraction
also displayed significant analgesic activity between 70.03 to 100 % inhibition of the contraction
of the abdominal muscle and stretching of the hind limbs at a dose of 75 to 300 mg/kg body
weight respectively, where ketoprofen had a 76.60 % inhibition. The fraction had significant
anti-inflammatory activity in carrageenan induced paw oedema model with maximum activity up
to three hours (60.0 % at first hour, 47.47 % at second hour, 65.38 % at third hour and 63 % at
fourth hour) at a dose of 150 mg/kg body weight. The ethyl acetate fraction of P. Pinnata leaf
poses significant analgesic and anti-inflammatory activities.
Description
Keywords
Paullinia pinnata, Acute Toxicity, Analgesic, Anti-inflammatory