Anacardium occidentale and Psidium guajava effectively reduced ethanol- induced gastric ulcer in male Wistar rats.
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Date
2016
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Journal ISSN
Volume Title
Publisher
College of Health Sciences
Abstract
Ulcer is one of the world‟s major gastrointestinal disorders affecting a good
percentage of the populace in industrialised and developing countries. Plant
extracts are some of the most attractive sources of new drugs and have shown
promising results for the treatment of gastric ulcer as they possess a variety of
natural therapeutic products. This study aimed to look at the effect of combining
Anacardium Occidentale and Psidium Guajava on the management of gastric
ulcer. The extracts of the leaves of Anacardium occidentale and Psidium guajava
were tested in ethanol-induced ulcer models in rats. Oral administration of these
plant extracts and reference drug was done for two weeks for 30 male Wistar rats
divided into five (5) groups. The treatment with the combination of the extract
stock solutions at a dose of 150mg/kg each exhibited a significant (p < 0.05)
decrease in gastric volume, 2.1x10-3 mEq/L and ulceration, 2.0±0.26 than the
individual extract groups when compared to control 4.0x10-3 mEq/L and
5.2±0.60 respectively while cimetidine at the dose tested had the highest
percentage reduction. The efficacy of the extracts presented here confirms that
the combination of Anacardium occidentale and Psidium guajava possess better
synergistic ulcer healing and gastro protective effects than the individual
components. This affirms their efficacy in the management of ulcers
Description
Keywords
Gasric ulcer, Anacardium occidentale, Psidium guajava, Cimetidine, Ethanol, Gastric acid Secretion, Male Wistar rats
Citation
A.O. Oyabambi et. al