Thymoquinone Ingestions Reversed Inflammation Driven Glia activation and Impaired Cognitive associated behavior in Cypermethrin Exposed Rats.

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dc.contributor.authorImam, A. L.
dc.contributor.authorOkesina, A. A.
dc.contributor.authorSulaimon, F. A.
dc.contributor.authorImam, A.
dc.contributor.authorIbiyeye, R. Y.
dc.contributor.authorAdana, M. Y.
dc.contributor.authorOmoola, O. O.
dc.contributor.authorAjao, M. S.
dc.date.accessioned2025-05-09T18:05:14Z
dc.date.available2025-05-09T18:05:14Z
dc.date.issued2024
dc.description.abstractBackground: Pyrethroids pose health risks to humans. Therefore, it is imperative to assess the preventive benefits of thymoquinone against neurotoxicity induced by cypermethrin- in the hippocampal dentate gyrus. Methods: Forty male adult Wistar rats with an average weight of 180-200g were randomly allocated to five (5) groups, and each comprising eight rats (n=8 per group). The groups were designated as follows, through oral administrations for 14 days: 0.5ml phosphate- buffered saline (PBS) was given to group one; Group two received 20mg/kg of cypermethrin (CYM); Group three received 10 mg/kg of thymoquinone (THQ); Group four received 20 mg/kg of cypermethrin followed by 10mg/kg of thymoquinone (CYM-10mgTHQ); and Group five received 20mg/kg and 5mg/kg cypermethrin and thymoquinone respectively (CYM-5mgTHQ). Behavioral, histological, immunohistochemical, and biochemical analyses were conducted post-treatment. Results: Cypermethrin administration caused the rise in pro-inflammatory cytokine TNF-α and increased expression of astrocytes, microglia, and pro-apoptotic protein Bax. Additionally, cypermethrin reduced levels of anti-inflammatory cytokine IL-10, acetylcholinesterase (AChE) activity, and nuclear factor erythroid 2-related factor 2 (Nrf2). cytoarchitectural disruption of dentate gyrus and decreased Nrf2 expression were observed. Cognitive deficits were evident. Thymoquinone treatment attenuated TNF-α elevation, reduced astrocyte, microglial, and Bax expression, and increased IL-10, AChE, and Nrf2 levels. Conclusion: Thymoquinone demonstrated anti-inflammatory and anti-apoptotic effects against cypermethrin-induced neurotoxicity, improving cognitive function in rats.
dc.identifier.citationImam, A. L., Okesina, A. A., Sulaimon, F. A., Imam, A., Ibiyeye, R. Y., Adana, M. Y., Omoola, O. O., & Ajao, M. S. (2024). Thymoquinone Ingestions Reversed Inflammation Driven Glia activation and Impaired Cognitive associated behavior in Cypermethrin Exposed Rats. The Journal of Neurobehavioral Sciences, 11 (2), 38-44
dc.identifier.urihttps://dergipark.org.tr/en/pub/jnbs/issue/86769
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16614
dc.publisherUskudar University
dc.subjectPyrethroids
dc.subjectAstrocytes
dc.subjectMicroglia
dc.subjectDentate gyrus
dc.subjectNrf2.
dc.titleThymoquinone Ingestions Reversed Inflammation Driven Glia activation and Impaired Cognitive associated behavior in Cypermethrin Exposed Rats.
dc.typeArticle

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