Assessment of Environmental Factors on Secondary Metabolites and Toxicological Effects of Datura metel Leaves Extracts

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dc.contributor.authorAbdul, Raheem
dc.contributor.authorAdenike, Modinah Oladayo
dc.contributor.authorSulaiman, Faoziyat Adenike
dc.contributor.authorAhmad, Olatunde Abdulrahim
dc.contributor.authorHalimat Amin, Yusuf
dc.contributor.authorOlaniyi, Kamil
dc.contributor.authorMukadam, Abdulrahman Abdullah
dc.contributor.authorGaniya, Latifat Oluwatobi
dc.contributor.authorKamilu, Ahmed Lateef
dc.contributor.authorOladepo, Khadijat Busola Alimi
dc.contributor.authorGrace, Oluwakemi
dc.contributor.authorAfolayan, Daniel
dc.contributor.authorOdeniran, Taiwo
dc.date.accessioned2020-01-30T11:11:42Z
dc.date.available2020-01-30T11:11:42Z
dc.date.issued2018
dc.descriptionThe leaves of D. metel has been investigated in this study and confirmed to contain some bioactive compounds such as alkaloids, steroids, glycosides, flavonoids, terpenoids and saponins, which provides a promising baseline for the traditional medicinal property. There is possibility that D. metel plant extracts can serve as a potent source for the development of natural antibacterial, antimicrobial, anticholinergic, antiinflammatory, antioxidant and anticancer agents as evident from GC-MS results. Thus, D. metel extracts may also be used to eliminate pathogenic organisms especially when collected in the evening and extracted with ethanol. Though, there is need to select harvesting time and extraction solvent based on the ailment of interest for treatment. These results confirmed that the bioactive compounds present in this plant are dependent on time of harvest and the choice of solvent used for extraction. Thus, from this study, the best time to harvest is evening and choice of solvent that revealed all the six phytoconstituents was ethanol.en_US
dc.description.abstractThis study evaluated the chemical composition, physicochemical properties, toxicological and environmental potentials of the Datura metel (D. metel) leaves extracts. Fresh leaves of D. metel were harvested at three different times of the day (morning, afternoon and evening), extraction done in succession using n-hexane and ethanol solvents respectively. Preliminary phytochemical screening, physicochemical analysis for specific gravity, pH, colour, total ash and moisture contents of the dried extracts were determined. The characterisation of the bioactive compounds using Gas Chromatography-Mass Spectrometry, showed the presence of different compounds at the three different times of the day, out of which phytol and 9,12,15-octadecatrienoic acid were present at all times. These results confirmed that some bioactive compounds present in this plant are dependent on environmental factor , time of harvest and the choice of solvent used while the presence of others are independent on these factors. Each extract was administered orally to Wistar rats for two weeks. There were significant difference (p < 0.05) in activities of AST (serum and heart), ALT (liver and serum) and ALP (Serum, liver and kidney), as well as the concentrations of albumin and protein in the liver and serum and urea in the serum of experimental rats given n-hexane and ethanolic extracts of D. metel. Generally it also suggest that the leaf extracts collected at three different times of the day had some significant toxicological effect, thus may not be totally safe for consumption at the dosage indicated since tissues membranes integrity of the Wistar rats were not potentially preserved.en_US
dc.description.sponsorshipAuthors wish to acknowledge the efforts of Miss. Olagunju, M.T for searching out the habitat of the plant. We thank the management of Herbarium, Plant Biology Department, University of Ilorin for the assistance rendered in the correct identification of the species used.en_US
dc.identifier.citationAbdul Raheem, Adenike Modinah Oladayo, Sulaiman, Faoziyat Adenike, Ahmad, Olatunde, Abdulrahim, Halimat Amin, Yusuf, Olaniyi Kamil, Mukadam, Abdulrahman Abdullah, Ganiya, Latifat Oluwatobi, Kamilu, Ahmed Lateef, Oladepo Khadijat Busola Alimi, Grace Oluwakemi, Afolayan Daniel, Odeniran, Taiwo. (2018). Assessment of Environmental Factors on Secondary Metabolites and Toxicological Effects of Datura metel Leaves Extracts. Annals of science and Technology (AST). An official journal of the Nigerian Young Academy. Volume 3 (1) Page 7-11. http://www.degruyter.com/view/j/ast.2018.3.issue-2/ast-2018-0015/ast-2018-0015.xml; Annals of Science and Technology 10.2478/ast-2018-0015.en_US
dc.identifier.issn2 544 6320
dc.identifier.urihttp://hdl.handle.net/123456789/3609
dc.language.isoen_USen_US
dc.publisherAnnals of science and Technology (AST)en_US
dc.subjectDatura metelen_US
dc.subjectPhotochemical reactionsen_US
dc.subjectGC-MSen_US
dc.subjectPhytochemicalen_US
dc.subjectToxicological studiesen_US
dc.titleAssessment of Environmental Factors on Secondary Metabolites and Toxicological Effects of Datura metel Leaves Extractsen_US
dc.typeArticleen_US

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