Phoenix dactylifera polyphenols ameliorates monosodium glutamate induced cell damage in the dentate gyrus
No Thumbnail Available
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Krishna Institute of Medical Sciences
Abstract
Background: Monosodium Glutamate (MSG) use is
quite alarming considering the cascades of toxicity
that arises from it. However, this study demonstrated
the possible ameliorative activities of polyphenols of
Phoenix dactylifera (PPD) on MSG-induced dentate
gyrus degeneration in male adult Wistar rats. Aim and
Objectives: To check the effects of PPD on MSG induced dentate gyrus neuronal damage in adult male
Wistar rats. Material and Methods: Groups A to D of
adult male rats underwent 14-day treatment of Normal
Saline (NS), 500 mg ̸ kg PPD, 4 mg ̸g of MSG only, and
4 mg̸g MSG and 500 mg/kg PPD (MSG+PPD)
concurrently. Group E received 500 mg ̸ kg PPD for a
14-day period prior to another 14-day of 4mg ̸ gMSG
(PPD then MSG). Results: PPD was able to ameliorate
the toxic effect of MSG as evidence of better cellular
integrity, minimal cell vacuolations, minimized
dispersed Nissl bodies and deeply stained Nissl bodies
were observed upon PPD administration. It was also
observed that it reduced the proliferation of reactive
oxygen species, proteins and DNAdamage in the cells
of the dentate gyrus. Conclusion: The study concluded
that PPD was able to ameliorate the degeneration
induced by MSG in the dentate gyrus of Wistar rats
Description
Keywords
Phoenix dactylifera, Polyphenols, Monosodium glutamate, Dentate gyrus
Citation
Usman, R. Y., Sulaimon, F. A., Okesina, A. A., Imam, A., Imam, A. L., & Ajao M. S (2021). Phoenix dactylifera polyphenols ameliorates monosodium glutamate induced cell damage in the dentate gyrus. Journal of Krishna Institute of Medical Sciences University. 10 (2), 139-145