Effect of increasing concentration of Acacia sieberiana gum on both matrix granules and tablet properties of chloroquine phosphate and metronidazole tablets

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dc.contributor.authorShittu, A.O.
dc.contributor.authorOyi A.R.
dc.contributor.authorOnaolapo, J.A.
dc.date.accessioned2024-05-13T08:43:55Z
dc.date.available2024-05-13T08:43:55Z
dc.date.issued2010
dc.description.abstractThe effect of increasing concentrations of a locally sourced A. sieberiana gum on the granules and tablet properties of chloroquine and metronidazole tablets was investigated in the gum matrix formulation. Varying concentrations 10-60%w/v of A. sieberiana gum composition in the tablet formulation was evaluated. Matrix tablets were formulated via the wet granulation method with 5%w/v maize starch mucilage as binder and at compression pressure of 3.5 x 105 N/m2. Mean granule size was greater than 500m. Flow properties of granules were optimal with average of 4.1g/sec for chloroquine phosphate matrix and 3.5g/sec for metronidazole matrix. Tablets prepared revealed that 50%w/w composition of gum produced the best quality in terms physico mechanical properties base friability, crushing strength and weight variation. Dissolution rate studies revealed T 90% for metronidazole matrix tablet and chloroquine phosphate matrix tablet as 1hr 45min and 50 min respectively. The gum shows better retardant effect with metronidazole than chloroquine phosphate
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/14114
dc.language.isoen
dc.publisherFaculty of Pharmaceutical Sciences, Ahmadu Bello University Zaria
dc.relation.ispartofseries9; 1
dc.subjectAcacia sieberiana gum
dc.subjectMatrix granules
dc.subjectMatrix tablets
dc.titleEffect of increasing concentration of Acacia sieberiana gum on both matrix granules and tablet properties of chloroquine phosphate and metronidazole tablets
dc.typeArticle

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