Effect of increasing concentration of Acacia sieberiana gum on both matrix granules and tablet properties of chloroquine phosphate and metronidazole tablets
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Date
2010
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Faculty of Pharmaceutical Sciences, Ahmadu Bello University Zaria
Abstract
The effect of increasing concentrations of a locally sourced A. sieberiana gum on the granules and tablet properties of chloroquine and metronidazole tablets was investigated in the gum matrix formulation. Varying concentrations 10-60%w/v of A. sieberiana gum composition in the tablet formulation was evaluated. Matrix tablets were formulated via the wet granulation method with 5%w/v maize starch mucilage as binder and at compression pressure of 3.5 x 105 N/m2. Mean granule size was greater than 500m. Flow properties of granules were optimal with average of 4.1g/sec for chloroquine phosphate matrix and 3.5g/sec for metronidazole matrix. Tablets prepared revealed that 50%w/w composition of gum produced the best quality in terms physico mechanical properties base friability, crushing strength and weight variation. Dissolution rate studies revealed T 90% for metronidazole matrix tablet and chloroquine phosphate matrix tablet as 1hr 45min and 50 min respectively. The gum shows better retardant effect with metronidazole than chloroquine phosphate
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Keywords
Acacia sieberiana gum, Matrix granules, Matrix tablets