Dengue virus and malaria concurrent infection among febrile subjects within Ilorin metropolis, Nigeria

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dc.contributor.authorKolawole, Olatunji Matthew
dc.contributor.authorSeriki, Adebimpe Adetola
dc.contributor.authorIrekeola, Ahmad Adebayo
dc.contributor.authorBello, Kizito Eneye
dc.contributor.authorAdeyemi, Oluwapelumi Olufemi
dc.date.accessioned2021-08-24T10:40:06Z
dc.date.available2021-08-24T10:40:06Z
dc.date.issued2017
dc.description.abstractDengue is a mosquito-borne disease of public health importance. It is caused by four serotypes of Dengue virus (i.e, DENV-1, -2, -3, and -4). As a result of practices that are conducive for mosquito breading, its vector is widespread in Nigeria and this could result to possible DENV outbreaks in Nigeria and beyond. This study aimed to assess the recency of DENV infection as well as occurrence ofDENVand Malaria co-infections within Ilorin, Nigeria. Blood samples were obtained from 176 febrile subjects and analyzed using Enzyme Linked Immunosorbent Assay (ELISA) for the presence of DENV antibodies. Malaria infection was detected using a rapid diagnostic test kit for malaria parasites. Malaria and DENV (IgM positive) co-infected samples were further subjected to RT-qPCR analysis. A seroprevalence of 46.0% was recorded for anti-DENV IgM antibodies and 2.84% for concurrent Dengue and malaria infections. Out of 95 IgM negative samples, 48 were found to be positive for DENV IgG antibodies. Eleven (6.25%) samples were confirmed DENV positive following RT-qPCR. The CT values of the amplicons were between 19.0 and 20.0. DENV serotype 2 dominated the study, while serotype 3 and 4 were equally distributed. Based on the high seroprevalence of DENV obtained in this study, there is a high possibility of experiencing Dengue virus outbreak in Ilorin, Nigeria, not neglecting the fast geographical spread of the vector. Therefore, surveillance and intensive vector control program should be instituted.en_US
dc.description.sponsorshipThis research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectorsen_US
dc.identifier.citationKolawole O.M., Seriki A.A., Irekeola A.A., Bello K.E., Adeyemi O.O. (2017). Dengue virus and malaria concurrent infection among febrile subjects within Ilorin metropolis, Nigeria. Journal of Medical Virology. 89(8); 1347–1353en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/6255
dc.language.isoenen_US
dc.publisherWiley-Blackwell, USAen_US
dc.titleDengue virus and malaria concurrent infection among febrile subjects within Ilorin metropolis, Nigeriaen_US
dc.typeArticleen_US

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