Controlled electrostatic self-assembly of ibuprofen-cationic dextran nanoconjugates prepared by low energy green process – a novel delivery tool for poorly soluble drugs

Simple item page
dc.contributor.authorAbioye, Amos Olusegun
dc.contributor.authorKola-Mustapha, Adeola
dc.date.accessioned2018-03-28T10:48:37Z
dc.date.available2018-03-28T10:48:37Z
dc.date.issued2015-06
dc.description.abstractPURPOSE: The direct effect of electrostatic interaction between ibuprofen and cationic dextran on the system-specific physicochemical parameters and intrinsic dissolution characteristics of ibuprofen was evaluated in order to develop drug-polymer nanoconjugate as a delivery strategy for poorly soluble drugs. METHODS: Amorphous ibuprofen-DEAE dextran (Ddex) nanoconjugate was prepared using a low energy, controlled amphiphile-polyelectrolyte electrostatic self-assembly technique optimized by ibuprofen critical solubility and Ddex charge screening. Physicochemical characteristics of the nanoconjugates were evaluated using FTIR, DSC, TGA, NMR and SEM relative to pure ibuprofen. The in vitro release profiles and mechanism of ibuprofen release were determined using mathematical models including zero and first order kinetics; Higuchi; Hixson-Crowell and Korsmeyer-Peppas. RESULTS: Electrostatic interaction between ibuprofen and Ddex was confirmed with FT-IR, (1)H NMR and (13)C NMR spectroscopy. The broad and diffused DSC peaks of the nanoconjugate as well as the disappearance of ibuprofen melting peak provided evidence for their highly amorphous state. Low concentrations of Ddex up to 1.0 × 10(-6) g/dm(3) enhanced dissolution of ibuprofen to a maximum of 81.32% beyond which retardation occurred steadily. Multiple release mechanisms including diffusion; discrete drug dissolution; anomalous transport and super case II transport were noted. CONCLUSIONS: Controlled assembly of ibuprofen and Ddex produced a novel formulation with potential extended drug release dictated by Ddex concentration.en_US
dc.identifier.citationMagnetically Controlled Drug Release System through Magnetomechanical Actuation by Barbosa J et alen_US
dc.identifier.urihttp://hdl.handle.net/123456789/200
dc.language.isoenen_US
dc.publisherPharmaceutical Researchen_US
dc.subjectAmorphous ibuprofen-Ddex nanoconjugate,en_US
dc.subjectControlled electrostatic self-assembly,en_US
dc.subjectOw energy green process,en_US
dc.subjectMultiple release mechanisms,en_US
dc.subjectParticle surface modificationen_US
dc.titleControlled electrostatic self-assembly of ibuprofen-cationic dextran nanoconjugates prepared by low energy green process – a novel delivery tool for poorly soluble drugsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Abstract Controlled Electrostatic Assembly.docx
Size:
12.9 KB
Format:
Microsoft Word XML
Description:
Abstract
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections