A Neuro-Fuzzy Framework for Finding Clinical Trials in the Drug Discovery Process
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Computing, Information Systems, Development Informatics & Allied Research Journal (CISDIAR)
Abstract
The drug discovery process is complex, time consuming and very expensive. Typically, the time to develop a candidate drug is
about 5 years, while the clinical phases leading, possibly, to the commercial availability of the drug are even longer (>7 years) for
a total cost of more than 700 Million dollars. Declining pharmaceutical industry productivity is well recognized by drug
developers, regulatory authorities and patient groups. A key part of the problem is that clinical studies are increasingly expensive,
driven by the rising costs of conducting Phase II and III trials. It is therefore crucial to ensure that these phases of drug
development are conducted more efficiently and cost-effectively, and that attrition rates are reduced.In this paper, a neuro-fuzzy
framework is presented for finding clinical trials in the drug discovery process. The proposed framework was developed based on
the combination of two artificial intelligence techniques known as artificial neural networks and fuzzy logic.
Description
Keywords
Clinical Trial, Drug Discovery, Preclinical, Drug Target, Placebo