A new sesquiterpene, prosoterpene, from Prosopis africana (Guill. & Perr.) Taub.
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Natural Product Research
Abstract
A new sesquiterpene (Prosoterpene, 1) and eleven reported compounds
(2–12) of several classes, such as flavonoids, alkaloids,
phenolic acids, and long-chain alcohols, were isolated from the
BuOH extract of Prosopis africana (Guill. & Perr.) Taub.
Compounds 2–10 were reported for the first time from this plant.
Isomers 11 and 12 were separated for the first time. Extensive
spectroscopic techniques and literature comparisons were used to
characterise their structures. Furthermore, compounds 3, 5–8, and
10–12 were performed for anti-glycation and cytotoxicity activities.
Compound 3 (quercetin-3-O-a-L-rhamnoside) exhibited moderate
anti-glycation activity. All tested compounds were noncytotoxic
against MCF-7 (breast cancer), NCI-H460 (lung cancer),
Hela (cervical cancer), and BJ (normal human fibroblast) cell lines.
Description
Keywords
Prosopis africana; sesquiterpene; prosoterpene; quercetin-3-O-a-Lrhamnoside; anti-glycation