EFFECT OF VERNONIA AMYGDALINA AND FISH OIL SUPPLEMENTED BISCUITS ON LIPID PROFILE PARAMETERS AND BLOOD GLUCOSE CONCENTRATION OF DIABETIC RATS
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Date
2024
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Publisher
Faculty of Science, Kaduna State University
Abstract
Biscuit, a popular snack, serve as an ideal vehicle for incorporating
therapeutic agents for disease management. This study aimed to
assess the effect of Vernonia amygdalina (VO) and fish oil (FO)-
supplemented biscuits (VFSB) on the total lipid profile and blood
glucose concentration of diabetic rats. Forty-nine Wistar rats were
allocated into seven groups (A to G). Upon induction and
confirmation of diabetes in experimental rats, fasting blood glucose
(FBG) level were monitored weekly using glucometer. Twenty-four
hours after the last day of treatment, rats were sacrificed and serum
total cholesterol (TC), triglyceride (TG), High-density lipoprotein
cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL c) concentrations were assayed using assay kits. Results showed
a significant (p < 0.05) reduction in FBG, TC, LDL-c, and TG
concentrations in biscuit fed groups D, E, and F compared to group
B fed VFSB. High-density lipoprotein cholesterol levels significantly
increased (p < 0.05) in groups D, E, and F compared to Group B.
In conclusion, Vernonia amygdalina and fish oil-supplemented
biscuits exhibited a glucose-lowering effect and mitigated
dyslipidemia associated with diabetes mellitus.
Description
Keywords
Therapeutic biscuit, diabetes mellitus, Heteroclarias, Vernonia, Lipids.