Antibiotic Susceptibility Profile of Uropathogens Isolated from Pregnant Women in Selected Hospitals in Ilorin

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dc.contributor.authorOLUFADI-AHMED, HAISAT Y.
dc.contributor.authorALIYU, ABDULMALIK
dc.contributor.authorDAVID, SUSAN M
dc.contributor.authorKOLA-MUSTAPHA, A. T.
dc.contributor.authorDIYAOLU, A. H.
dc.date.accessioned2021-05-06T09:09:45Z
dc.date.available2021-05-06T09:09:45Z
dc.date.issued2019
dc.description.abstractBackground: Urinary tract infection (UTI) is one of the most common infections among pregnant women and if untreated could lead to serious complications. Objective: This work was carried out to determine the prevalence rate of Enterobacteriaceae uropathogens and their antibiotics susceptibility profile among pregnant women attending two ante-natal clinics in Ilorin, Nigeria. Materials and Methods: A total of 111 pregnant women between the ages of 18-50 attending ante-natal clinic at University of Ilorin Teaching Hospital and Civil Service Hospital, Ilorin participated in the study. Mid-stream urine samples were collected and cultured on Cysteine-Lactose-Electrolyte Deficient agar. Presence of significant bacteriuria (> 105 cfu/mL) was determined using the plate count method. Antibiotic susceptibility testing was done using Kirby-Bauer disk diffusion technique. Results: Of the 111 urine samples collected, 27.9% of them were found positive on culture. Among the isolated organisms, Klebsiella oxytoca (25.7%) followed by Klebsiella pneumonia (22.9%), were the most prevalent. Isolated bacteria were resistant to at least one antibiotic with the highest resistance seen with amoxicillin (94.3%), streptomycin (77.1%) and nitrofurantoin (54. 3%). Amoxicillin-clavulanic acid (51.4%), ceftriaxone (51.4%), ceftazidime (34.3%), cotrimoxazole (51.4%), imipenem (2.9%), ciprofloxacin (14.3%) and gentamicin (25.7%) have the lowest rate of bacteria resistance. Of the isolates, 82.9% showed Multi-Antibiotic Resistance Index (MARI) ≥ 0.3. Conclusion: High prevalence of bacteriuria in both symptomatic and asymptomatic pregnant women was observed in the study areas. The alarming rate of multi-antibiotic resistance strain is therefore an indicator of a serious clinical problem in the community.en_US
dc.description.sponsorshipSelfen_US
dc.identifier.citationOlufadi-Ahmed et al., 2019en_US
dc.identifier.issn0189-8434
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5046
dc.publisherNigerian Journal of Pharmaceutical Researchen_US
dc.subjectBacteriuriaen_US
dc.subjecturine cultureen_US
dc.subjectpregnancyen_US
dc.subjectantibiotic susceptibilityen_US
dc.titleAntibiotic Susceptibility Profile of Uropathogens Isolated from Pregnant Women in Selected Hospitals in Ilorinen_US
dc.typeArticleen_US

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