Design, Formulation and Characterization of Ibuprofen-Polyethylene Glycol (6000) Solid Dispersions
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Date
2019
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Publisher
West African College of Postgraduate Pharmacists
Abstract
Background: Formulation of solid dispersion has attracted considerable interest where dispersing a poorly water soluble drug in a water soluble polymer matrix improves the dissolution characteristics and bioavailability of the drug.
Aim: The aim of this study was to enhance the dissolution rate and bioavailability of Ibuprofen (BCS class II) using solid dispersion techniques.
Method: Ibuprofen solid dispersion was prepared by fusion method. Drug-carrier physical mixtures were also prepared. Effects of polyethylene glycol 6000 (PEG 6000) was studied for the solid dispersions and physical mixtures. The solid dispersions were investigated for drug content, solubility and dissolution characteristics, surface morphology using optical microscopy and Fourier Transform Infrared Spectroscopy (FTIR). All the solid dispersions showed better solubility characteristics and dissolution rate than physical mixtures. Evaluation of the FTIR results shows that the stretching vibration of ibuprofen carbonyl peak in SDs and physical mixture remained which indicates that the drug crystalline form may not be altered during solid dispersion formation and its attenuated intensities were thought to be due to the lower drug content as the amount of polymer was increased.
Conclusion: The FT-IR and DTA results for SDs and physical mixtures showed no drug-polymer interaction. The statistical analysis, solubility and dissolution rate test result of ibuprofen was compared to that of the SD formulations and the values obtained were significantly below 0.05 which indicates that the results are
statistically significant. Therefore, solid dispersion may be an effective technique to enhance dissolution rate of Ibuprofen.