Moringa Oleifera is protective against microarchitectural and neurochemical changes associated with cuprizone-induced pre-frontal cortex neurotoxicity in female Wistar rats

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dc.contributor.authorOmotoso G.O.
dc.contributor.authorGbadamosi I.T.
dc.contributor.authorAkinlolu A.A.
dc.contributor.authorAmeen M.O.
dc.contributor.authorKadir R.E.
dc.contributor.authorJaji-Sulaimon R.
dc.contributor.authorAbdulwahab A.B.
dc.contributor.authorKolo R.M.
dc.date.accessioned2025-05-02T11:26:01Z
dc.date.available2025-05-02T11:26:01Z
dc.date.issued2018
dc.description.abstractCuprizone administration causes selective damage to axonal myelin sheath and has been used to model demyelinating diseases in neuroscience research. This study aimed at determining the protective effects of Moringa oleifera on cuprizone-induced neurotoxicity in the prefrontal cortex (PFC). Sixteen adult female Wistar rats were procured and grouped into 4: Group A was given normal saline, Group B received 0.4% cuprizone diet, Group C was administered with 1.875 mg/ml of Moringa oleifera and Group D received a combination of 0.4% cuprizone diet and 1.875 mg/ml of Moringa oleifera. All the groups were treated orally for 35 consecutive days after which they were sacrificed. Thereafter the PFC was processed for histological demonstration, while tissue homogenate was used to assay the activity of superoxide dismutase (SOD). Cuprizone administration caused significant reduction in body weight and SOD activities. It also caused an alteration in the microarchitecture and Nissl profile of the PFC. Moringa oleifera intervention led to restoration of body weight, SOD levels, Nissl profile and the histology of the PFC. The use of preparations of Moringa oleifera, especially the leaf-component, could offer some protective measures to individuals suffering from demyelinating conditions, especially in addressing the associated weight changes and frontocortical dysfunction.
dc.identifier.citationOmotoso G.O., Gbadamosi I.T., AkinloluA.A., Ameen M.O., Kadir R.E., Jaji-Sulaimon R., Abdulwahab A.B. & Kolo R.M. (2018). Moringa Oleifera is protective against microarchitectural and neurochemical changes associated with cuprizone-induced pre-frontal cortex neurotoxicity in female Wistar rats. Nigerian Journal of Neuroscience. 9(2): 47-52. Published by Neuroscience Society of Nigeria. Available online at https://njn.neurosociety.org.ng/publication/index.php
dc.identifier.issn1116-4182
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15858
dc.language.isoen
dc.publisherNeuroscience Society of Nigeria
dc.relation.ispartofseriesVol 9, Issue 2; 47-52
dc.subjectCuprizone
dc.subjectDemyelination
dc.subjectMoringa oleifera
dc.subjectWeight
dc.subjectPrefrontal cortex
dc.titleMoringa Oleifera is protective against microarchitectural and neurochemical changes associated with cuprizone-induced pre-frontal cortex neurotoxicity in female Wistar rats
dc.typeArticle

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