Cost-Minimization Analysis of Antimicrobial Therapy in A Tertiary Healthcare institution in Nigeria
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Date
2008
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Published by Faculty of Pharmaceutical Sciences, University of Jos.
Abstract
Cost Minimization Analysis of antimicrobial therapy in a tertiary health care institution in a developing economy
country was carried out. The most applicable tool for generic equivalent drugs was used in Ahmadu Bello
University Teaching Hospital, a tertiary healthcare Institution in Nigeria, between 2005 and 2007. Relevant
information such as diagnosis, cost of drugs (in Naira – N), dosage, duration of therapy among others were obtained
retrospectively from patient case-notes for which antibacterial are the mainstay of therapy and dispensed
prescriptions. The mean cost per defined daily dosage (DDD) of generic and branded for each antibacterial was
computed. These were compared using Student’s t-test. The outcome measure was potential eradication of bacterial
in question by the respective antibacterial drug. The analyses showed that the use of expensive branded drugs were
very rampant even when the much cheaper generic equivalent is available. The differences in the mean cost/DDD
were very significant for all the antimicrobial agents at p<0.05. For example the mean cost/DDD of ciprofloxacin
was N267 for branded product and N80.00 for generic (t = 421.2 at p<0.05).Sensitivity analysis also Confirm this
decision. Prescriptions of expensive branded drugs were rampant even when the much cheaper generic equivalents
are available. The mean cost per Defined Daily Dose of Branded and Generic equivalent were significantly different
for all antibiotics applicable for cost minimization analysis, with Generic Products much cheaper than Branded
equivalent.
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Keywords
Pharmacoeconomics;, Cost-minimization analysis;, Antimicrobial;, Generic;, Branded
Citation
A. Giwa, G.K Osagbemi, R.F Atata and H.B.F Giwa (2008): Cost-Minimization Analysis of Antimicrobial Therapy in A Tertiary Healthcare institution in Nigeria. Journal of Pharmacy and Bioresources, 5(2); 47-51, Published by Faculty of Pharmaceutical Sciences, University of Jos