Study on comparison of serum levels of calcium, magnesium and uric acid in mild preeclamptics, severe preeclamptic and normal pregnant women in Ilorin, Nigeria
No Thumbnail Available
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Centre for Reproductive and Developmental Programming
Abstract
Background: Preeclampsia is pregnancy-specifi c syndrome and contributes about 15%
of maternal mortality and preterm deliveries. Objective: To compare the serum levels
of calcium, magnesium, and uric acid in mild preeclamptics, severe preeclamptics, and
normal pregnant women. Materials and Methods: A cross-sectional study conducted
at the Department of Obstetrics and Gynaecology of the University of Ilorin Teaching
Hospital (UITH) Ilorin. The data were collected from 64 normal pregnant women,
64 mild preeclamptic women, and 64 severe preeclamptic women who presented at
the Department of Obstetrics and Gynaecology, UITH between June 2013 and January
2014. The data were analyzed using analysis of variance. Results: The mean serum
calcium concentration in severe preeclamptics and mild preeclamptics was signifi cantly
reduced (1.75 ± 0.63 mmol/L and 1.90 ± 0.44 mmol/L vs. 2.28 ± 0.24 mmol/L, P = 0.00)
compared with serum calcium concentration in normal pregnant controls. The serum
magnesium concentration among severe preeclamptics was also signifi cantly reduced
(0.84 ± 0.44 mmol/L versus 1.05 ± 0.28 mmol/L, P = 0.00) compared with serum magnesium
among normal pregnant controls. However, there was no statistically signifi cant difference
in serum magnesium concentration between mild preeclamptic women and normal pregnant
women (1.01 ± 0.26 mmol/L vs. 1.05 ± 0.28 mmol/L). The serum uric acid concentration
was signifi cantly elevated among both mild and severe preeclamptic women compared with
the serum uric acid concentration among normal pregnant control (0.89 ± 0.63 mmol/L and
1.25 ± 0.68 mmo/L vs. 0.21 ± 0.19 mmol/L). Conclusions: It is concluded that while reduced
serum calcium levels and elevated serum uric acid levels correlate with etiopathogenesis
of preeclampsia, reduced serum magnesium correlates with severity of preeclampsia.
Description
Keywords
Pregnancy, Preeclampsia, Serum calcium, Serum magnesium, uric acid