Synthesis, Characterization and Biological activity of Metal Complexes Mixed Citric acid and Amodiaquine

Simple item page
dc.contributor.authorLawal, A.
dc.contributor.authorOlowude, S.
dc.contributor.authorBamigboye, M. O.
dc.contributor.authorSa`ad, H. O.
dc.contributor.authorNnabuike, G. G.
dc.contributor.authorYunus-Issa, M. T.
dc.contributor.authorAmolegbe, S. A.
dc.date.accessioned2019-10-30T09:17:30Z
dc.date.available2019-10-30T09:17:30Z
dc.date.issued2017-05-20
dc.description.abstractA range of d-block transition metals complexes of mixed amodiaquine and citric acid have been synthesized and characterised using microanalytical technique , elemental analysis, FT-IR spectroscopy and magnetic measurement. The results of the analytical and spectroscopic data revealed that both amodiaquine and citric acid acted as bidentate ligands in the ir mode of coordination with the metal ions.The citric acid bound through the carbonyl (C=O) and hydroxyl groups to the metal ions while, amodiaquine coordinated through the nitrogen atom of the amine and oxygen donor atom of hydroxyl group; resulted in structures with octahedral geometry. Percentage composition and magnetic Bohr moment data indicated that all metal complexes were paramagnetic. Molar conductance measurement indicates that the complexes are non-electrolytes in nature. The antimicrobial activity of the ligands and their mixed complexes was carried out against g(+)Pseudomonas aeruginosa, g(+)E. coli, g( +)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The citric acid and amodiaquine result showed low or moderate value from (0.6-0.8) for all the metal complexes with the exception of the Cu(II) complex having inhibitory zones ranging from 1-0-1. 3 , 0 . 7 - 0 . 9 at 200 ppm respectively. Moreover, the free ligands were found being less active compared with their mixed complexes.en_US
dc.identifier.issn2006 – 6996
dc.identifier.urihttp://hdl.handle.net/123456789/3122
dc.language.isoenen_US
dc.publisherFaculty of Science, Bayero University Kano. Nigeriaen_US
dc.subjectCitric aciden_US
dc.subjectAmodiaquineen_US
dc.subjectComplexesen_US
dc.subjectAntimicrobial studies.en_US
dc.titleSynthesis, Characterization and Biological activity of Metal Complexes Mixed Citric acid and Amodiaquineen_US
dc.title.alternativeBayero J. Pure and Applied Sciencesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
BAYERO JPAS - 2017 LAWAL ET AL.pdf
Size:
176.91 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections