Pharmaco-Economic Evaluation of Doxycycline and Tetracycline in the Treatment of Chlamydia implicated Non-Gonococcal Urethritis in a Tertiary Healthcare Institution in Nigeria.
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Date
2009-01
Journal Title
Journal ISSN
Volume Title
Publisher
African Society for Clinical Microbiology, LAUTECH Teaching Hospital
Abstract
ABSTRACT
With depressing nature of economy in many countries such as Nigeria where per capita income
is low, there is need for utmost consideration for cost containment measures.
Objective: The objective of this study is to conduct pharmacoeconomic evaluation of two antichlamydial indicated non-gonococcal urethritis therapeutic options and to make
recommendations for inclusion of economic evaluation of drug therapies in health policy
formulations and decision making.
Methods: Cost effectiveness analysis was carried out retrospectively for prescribed/dispensed
antibacterials to out-patients with chlamydial implicated non-gonococcal urethritis among
other infectious diseases, by examining out-patient case notes between 2005 and 2007 in
Ahmadu Bello University Teaching Hospital, Zaria Nigeria.
Results : The result shows that doxycycline costs N1.33/unit of effectiveness while tetracycline
costs N2.77/unit of effectiveness in the treatment of chlamydial implicated non-gonococcal
urethritis. Doxycycline is therefore more cost effective than tetracycline capsules. Subjecting
the costs and effectiveness to sensitivity analysis did not change this conclusion. There is
statistically significant difference in the effectiveness (outcome) of doxycycline (78.8%) and
tetracycline (58.7%) ( x2 =9.4; p<0.05) There is therefore association between effectiveness and
therapeutic option chosen with doxycycline being a more cost-effective option. The result is
significant because doxycycline is not currently included in the Essential Drug list of Nigeria1.
However, the result is in agreement with Zimbabwean Essential Drug list which recommended
that tetracycline be replaced by doxycycline in all indications and should be used only when
doxycycline is not available2. Also doxycycline is a drug of choice for other disease like
gonorrhorea and syphilis in non-pregnant women2. It was concluded that Doxycycline 100mg
bd x 1/52 is more cost effective than Tetracycline 500mg qid x 1/52 in the treatment of chlamydial
implicated non-gonococcal urethritis. Adoption of economic evaluation of drug therapies in
Nigeria Health policy formulation and decisions is likely to enhance overall Health System cost
effectiveness.
Description
Keywords
Pharmacoeconomics, Cost effectiveness analysis, Doxycycline, Tetracycline, Nongonocccal Urethritis.
Citation
Giwa A., Osagbemi G. K., Olayinka B. O., Giwa H. B. F. (2009): Pharmaco-Economic Evaluation of Doxycycline and Tetracycline in the Treatment of Chlamydia implicated Non-Gonococcal Urethritis in a Tertiary Healthcare Institution in Nigeria. African Journal of Clinical and Experimental Microbiology. 10 (1); 38-46, Published by African Society for Clinical Microbiology, LAUTECH Teaching Hospital. Available online at https://www.ajol.info/index.php/ajcem