The impact of systemic hypertension on outcomes in hospitalized COVID-19 patients – a systematic review.

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Faculty of Medicine, Makerere University, Uganda


Background: Several observational reports from different parts of the world have shown that systemic hypertension sion) was the single commonest comorbid condition in hospitalized COVID-19 patients. Hypertension is also the most comorbidity reported among patients who developed severe disease, were admitted to Intensive Care Unit, needed ventilatory support, or who died on admission. The objective of this systematic review is to study the association betwpertension and specific clinical outcomes of COVID-19 disease which are- development of severe COVID-19 diseaseadmission in the intensive care unit (ICU) or critical care unit (CCU), need for mechanical ventilation or death Methods: We searched the PubMed, SCOPUS, and Google Scholar databases up till June 28, 2020 for original researcthat documented the risk factors of mortality in patients with COVID-19 using the PRISMA guideline. Results: One hundred and eighty-two articles were identified using pre-specified search criteria, of which 33 met the sion criteria. Only three were prospective studies. Most studies documented hypertension as the most prevalent comorbidity association of hypertension with development of severe COVID-19 disease was not conclusive, majority of studies found an associated with mortality. Conclusion: Hypertension affects the clinical course and outcome of COVID-19 disease in many cohorts. Prospective studies are needed to further understand this relationship.



Keywords: Hypertension and COVID-19, SARS –Cov-2, severity, mortality, ICU care, mechanical ventilation.


African Health Sciences 22(4):505-518.