Compaction Characteristics of a Micro-structured Filler-binder “Microcrystarcellactose B3” for direct compression tableting
| dc.contributor.author | Shittu, A.O. | |
| dc.contributor.author | Oyi, A.R. | |
| dc.contributor.author | Isah, A.B. | |
| dc.contributor.author | Ibrahim, M.A. | |
| dc.date.accessioned | 2024-05-13T09:45:12Z | |
| dc.date.available | 2024-05-13T09:45:12Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | A research was conducted to develop and evaluate a highly compressible micro-structured filler- binder for direct compression tableting. Tapioca starch (TS) was annealed, hydrolyzed and coprocessed with α-lactose monohydrate (α-LMH) and microcrystalline cellulose (MCC) to yield a novel microcrystarcellactose (MSCL B3). The powder suspensions were prepared at a concentration of 40 %w/w in five separate conical flasks. The TS granules were annealed for 1 h and subsequently hydrolyzed with α-amylase at 58o and pH 7 for 1, 2, 3, 4, and 5 h respectively. The reaction was terminated and neutralized with 0.1 N HCL and 0.1 N NaOH respectively. The enzyme hydrolyzed starch (EHS) at 3 h, sieved fraction >75-250 μm was coprocessed with α-LMH and MCC and compressed with load ranging from 2.5 to 12.5 KN. MSCL B3 (component ratio of EHS, α-LMH, and MCC ‘35: 35:30’) possessed improved functionality over direct physical mixture of the excipients. The Py (yield values) are: Cellactose (24.2 MNm-2) > MCC (25 MNm-2) > MSCL B3 (50.0 MNm-2) > Starlac (143 MNm-2). The degree of plastic deformation occurring “Pk” are in the following order: MSCL B3 (17.0 MNm-2) = Cellactose ® (17.0 MNm-2) > MCC (18.6 MNm-2) > Starlac® (19.1 MNm-2). MSCL B3 is as good as Cellactose® and more superior in functionality than Starlac® and MCC. The dilution potential for MSCL B3 in PCM and AA tablets were: 45% and 50 % respectively. MSCL B3 can be used to formulate softer tablet of both poorly compressible API and moisture sensitive API | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/14147 | |
| dc.language.iso | en | |
| dc.publisher | Faculty of Pharmaceutical Sciences, University of Jos | |
| dc.relation.ispartofseries | 15; 2 | |
| dc.subject | Microcrystarcellactose | |
| dc.subject | Coprocessed Excipient | |
| dc.subject | Directly compressible Excipient | |
| dc.subject | Highly functional Filler-binder | |
| dc.subject | Tapioca Starch | |
| dc.title | Compaction Characteristics of a Micro-structured Filler-binder “Microcrystarcellactose B3” for direct compression tableting | |
| dc.type | Article |