Androgenic effects of aqueous extract of moringa oleifera in male Wistar rats.
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Date
2022
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School of Medicine and Health Sciences, University of Papua, New Guinea.
Abstract
Androgenic effects of Aqueous Seed-extract of Moringa oleifera (ASMO) in male Wistar rats were
investigated. Eighteen (18) male Wistar rats weighing 200-240g were used for this study. The rats were
divided into three (3) groups: Control (Group 1) that received 10 ml/kg of normal saline, Group 2:
received low dose of ASMO (200mg/kg), and Group 3: received high dose of ASMO (500mg/kg). The
animals were treated for twenty-eight days. On the 29th day, the rats were sacrificed and the testes
were carefully removed for semen and biochemical analysis. Body weight, reproductive and vital organ
weights were determined. Sperm parameters (motility, morphology, count and viability), tissue
testosterone, luteinizing hormone (LH), Malondialdehyde (MDA) and Catalase were also determined
using standard methods. Data were analysed using one-way ANOVA followed by Duncan new multiple
range post hoc test. The result showed ASMO significantly increased (p<0.05) the final body weight,
weight of reproductive and vital organs. Moreover, 200mg/kg body weight dose of ASMO significantly
increased (p<0.05) the sperm parameters but 500mg/kg body weight dose significantly decreased it.
ASMO also caused a significant dose dependent increase (p<0.05) in testosterone and catalase level
but a significant decrease (p<0.05) in MDA and LH level compared with the control. In conclusion, this
study revealed that ASMO has androgenic effects in male rats and thus provides a basis for the
traditional use of Moringa oleifera in the management of male sexual disorders
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Citation
Moringa oleifera, Testosterone, Malondialdehyde, Catalase, Sperm parameters