Effect of Chronic Cigarette Smoking on lipid profile – A Pilot study in North-Eastern Nigeria.
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Date
2016
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Journal ISSN
Volume Title
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Sokoto Journal of Medical Laboratory Science
Abstract
Abstract
Cigarette smoking is a major risk factor of atherosclerosis and
coronary artery disease. It has been linked with alterations in
lipid profile level but which fraction of lipids profile is affected by
cigarette smoking remains controversial. In this study we
evaluated the lipids profile among smokers in North-Eastern
Nigerian. Total Cholesterol (Tc), High Density Lipoprotein
Cholesterol (HDL-c) and Triglycerides (TG) were determined
colometrically but Low Density Lipoprotein Cholesterol (LDL-c)
was calculated. A total of One hundred and forty (140) current
smokers, Twelve (12) Ex-smokers and Eighty four (84) controls
were recruited. The current smokers were also categorized
based on daily cigarette consumption; Light (<5 sticks/Day),
Moderate (6-10 sticks/day) and Heavy (>10 sticks/day), and
duration of smoking; Short (5-10 years ), Medium (11-20years)
and Long (>20 years). Clinical history, daily cigarette
consumption and duration of smoking were obtained from a
semi–structured questionnaire. TC, LDL-c, and TG were all
significantly elevated in current smokers compared with control
(p<0.05) with a significant decrease in HDL level (p<0.05). They
all correlated with duration and quantity of daily cigarette
consumption. There was no significant difference between ex
smokers and control, except for the significant increase in TG
level observed. The results indicated an increased risk of
dyslipidaemia in cigarette smokers which is pro-atherogenic
and can potentially put smokers at a greater risk of
cardiovascular diseases.
Key words: Atherogenic indices, Atherosclerosis, Cholesterol;
Lipids; Cigarette smoking; Cardiovascular Disease.
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Citation
Atherogenic indices, Atherosclerosis, Cholesterol; Lipids; Cigarette smoking; Cardiovascular Disease.