Current Methods in the Characterization of Immune Mechanisms Involved in the Elicitation of Drug Hypersensitivity Reactions.
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Date
2019-04
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Abstract
Abstract
Adverse drug reactions (ADRs) remain a major health problem worldwide. Incidences of ADRs in the developing world have been documented by various studies, and this highlights the need for greater understanding of the molecular basis underlying these reactions in individuals with identified drug hypersensitivity. We review the general theories of immune stimulation by small molecules and the molecular basis of immune involvement in the manifestation and pathophysiology of ADRs. We then describe the methods used in the evaluation of drug hypersensitivity and in the identification of specific antigens (immunogens) which could be implicated in the pathogenesis of ADRs. This review also highlights the problems faced by researchers in resource deprived countries, and recommends important steps to solve these problems. We are of the opinion that a concerted effort should be made to develop the infrastructures needed in developing countries to encourage scientific research in this
burgeoning field of immunopharmacology.
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Keywords
Adverse Drug Reactions, Pharmacovigilance, , ELISpot, Peripheral blood mononuclear cell