Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
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Date
2021-06-17
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CellPress
Abstract
Background: Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management
of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and
antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats.
Methods: Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of
streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15
min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina
nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments
on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants
parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase
inhibition, lipase inhibition and histology of the organs were evaluated.
Results: Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in
fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, lowdensity
lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic
α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase
in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide
dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of
the pancreatic tissue after treatment with AEPN.
Conclusions: This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin
–nicotinamide-induced type 2 diabetic rats.
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Keywords
Antioxidant, Diabetes, Parquetina nigrescens, Streptozotocin, Histology