Effect of sodium acetate on serum activity of glucose-6-phosphate dehydrogenase in Plasmodium berghei-infected mice
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Date
2020-10-11
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Journal ISSN
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Publisher
Springer
Abstract
Malaria is a global health problem with severe
morbidity and mortality in Sub-Saharan Africa. Resistance
of Plasmodium spp to the current anti-malaria drugs
necessitates further search for novel effective drugs. This
study, therefore, investigated the effect of sodium acetate
on glucose-6-phosphate dehydrogenase in Plasmodium
berghei-infected mice. Thirty male Albino mice were
randomly distributed into 6 groups, A–F. Animals in
Groups B–F were inoculated with P. berghei, intraperi toneally. Subsequently, Group C mice were treated with 20
mg/kg chloroquine, while groups D, E and F received 25,
50 and 100 mg/kg sodium acetate, respectively. All treat ments were administered orally for 4 days. At the end of
the experiment, animals were sacrificed by cervical dislo cation and blood was collected via cardiac puncture for the
analyses of serum glucose-6-phosphate dehydroge nase (G6PD), uric acid and lipid profile. Our results sho wed that Sodium acetate (50 and 100 mg/kg) significantly
reduced (p\ 0.05) parasitaemia (67.11% and 77.62%,
respectively) than chloroquine (61.73%). Besides, body
weight and serum G6PD activity in P. berghei infection
were improved. Similarly, sodium acetate reduced elevated serum uric acid. Effects of sodium acetate and chloroquine
on biochemical parameters were comparable (p [0.05)
but atherogenic lipid ratios were not affected by sodium
acetate. These data put together suggested that activity of
sodium acetate may be harnessed for development of novel
anti-malaria drugs. However, more studies are required to
delineate its mechanisms of action.
Description
Keywords
Sodium acetate, Plasmodium berghei, Uric acid, Lipid profile, G6PD