Kolaviron protects the brain in cuprizone-induced model of experimental multiple sclerosis via enhancement of intrinsic antioxidant mechanisms: Possible therapeutic applications?
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Date
2018
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Published by the International Society for Pathophysiology.
Abstract
Multiple sclerosis is a demyelinating condition of the central nervous system which commonly affects
young adults. Kolaviron, a biflavonoid isolate of Garcinia kola, has been used in experimental studies
which explored its anti-oxidative, anti-inflammatory and anti-genotoxic properties. This work was aimed
at unraveling the possible ameliorative effect of kolaviron on cuprizone-induced demyelination in the
prefrontal cortices of Wistar rats. A total of 28 adult male Wistar rats were divided into four groups
A–D. Group A received corn oil (Control), group B received 0.2% Cuprizone, group C received kolaviron
(200 mg/kg bw), while group D rats were treated concomitantly with both kolaviron and cuprizone. All
groups were treatedfor 42days, after whichbehavioral,histological,immunohistochemical andbiochem ical analyses were carried out on the prefrontal cortices. Cuprizone significantly down-regulated the level
of superoxide dismutase, exacerbated lipid peroxidation and, reduced spatial memory. Cuprizone also
induced peripheral and central chromatolysis alongside with atrophied astrocytes in the prefrontal cor tex. These alterations were significantly prevented in kolaviron-treated rats, as kolaviron sustained the
integrity of neuronal and non-neuronal cells. The activity of kolaviron observed in this study was due to
its intrinsic antioxidant properties, which enabled it to combat oxidative damage induced by cuprizone,
thereby making kolaviron a potential tool in neurodegeneration therapy of demyelination origin.
Description
Keywords
Cuprizone Demyelination Kolaviron Oxidative enzymes Prefrontal cortex
Citation
Omotoso, G. O., Ukwubile, I. I., Arietarhire, L., Sulaimon, F., & Gbadamosi, I. T. (2018): Kolaviron protects the brain in cuprizone-induced model of experimental multiple sclerosis via enhancement of intrinsic antioxidant mechanisms: Possible therapeutic applications? Pathophysiology. 25(4);299-306